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Basic mechanisms of migration

Migration in biological processes

Migration related articles

Basic mechanisms of migration

  • Petrie RJ, Doyle AD, Yamada KM. Random versus directionally persistent cell migration. Nat. Rev. Mol. Cell Biol. 2009; 10:538-49 PubMed.
  • Bretscher MS. On the shape of migrating cells--a 'front-to-back' model. J. Cell. Sci. 2008; 121:2625-8 PubMed.
  • Janetopoulos C, Firtel RA. Directional sensing during chemotaxis. FEBS Lett. 2008; 582:2075-85 PubMed.
  • Van Haastert PJ, Devreotes PN. Chemotaxis: signalling the way forward. Nat. Rev. Mol. Cell Biol. 2004; 5:626-34 PubMed.
  • Horwitz R, Webb D. Cell migration. Curr. Biol. 2003; 13:R756-9 PubMed.
  • Horwitz AR, Parsons JT. Cell migration--movin' on. Science 1999; 286:1102-3 PubMed.
  • Parent CA, Devreotes PN. A cell's sense of direction. Science 1999; 284:765-70 PubMed.

Migration in biological processes

  • Avraamides CJ, Garmy-Susini B, Varner JA. Integrins in angiogenesis and lymphangiogenesis. Nat. Rev. Cancer 2008; 8:604-17 PubMed.
  • Etienne-Manneville S. Polarity proteins in migration and invasion. Oncogene 2008; 27:6970-80 PubMed.
  • Machesky LM. Lamellipodia and filopodia in metastasis and invasion. FEBS Lett. 2008; 582:2102-11 PubMed.
  • Mackay CR. Moving targets: cell migration inhibitors as new anti-inflammatory therapies. Nat. Immunol. 2008; 9:988-98 PubMed.
  • Mierke CT, Rösel D, Fabry B, Brábek J. Contractile forces in tumor cell migration. Eur. J. Cell Biol. 2008; 87:669-76 PubMed.
  • Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev. Cell 2008; 14:818-29 PubMed.
  • Boldajipour B, Raz E. What is left behind--quality control in germ cell migration. Sci. STKE 2007; 2007:pe16 PubMed.
  • Keller R. Cell migration during gastrulation. Curr. Opin. Cell Biol. 2005; 17:533-41 PubMed.
  • Luster AD, Alon R, von Andrian UH. Immune cell migration in inflammation: present and future therapeutic targets. Nat. Immunol. 2005; 6:1182-90 PubMed.
  • Wang W, Goswami S, Sahai E, Wyckoff JB, Segall JE, Condeelis JS. Tumor cells caught in the act of invading: their strategy for enhanced cell motility. Trends Cell Biol. 2005; 15:138-45 PubMed.
  • Yamaguchi H, Wyckoff J, Condeelis J. Cell migration in tumors. Curr. Opin. Cell Biol. 2005; 17:559-64 PubMed.
  • Lehmann R. Cell migration in invertebrates: clues from border and distal tip cells. Curr. Opin. Genet. Dev. 2001; 11:457-63 PubMed.
  • Locascio A, Nieto MA. Cell movements during vertebrate development: integrated tissue behaviour versus individual cell migration. Curr. Opin. Genet. Dev. 2001; 11:464-9 PubMed.
  • Marín O, Rubenstein JL. A long, remarkable journey: tangential migration in the telencephalon. Nat. Rev. Neurosci. 2001; 2:780-90 PubMed.
  • Jones GE. Cellular signaling in macrophage migration and chemotaxis. J. Leukoc. Biol. 2000; 68:593-602 PubMed.
  • Maschhoff KL, Baldwin HS. Molecular determinants of neural crest migration. Am. J. Med. Genet. 2000; 97:280-8 PubMed.
  • Rakic P. Molecular and cellular mechanisms of neuronal migration: relevance to cortical epilepsies. Adv Neurol 2000; 84:1-14 PubMed.
  • Montell DJ. The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development. Development 1999; 126:3035-46 PubMed.
  • Sánchez-Madrid F, del Pozo MA. Leukocyte polarization in cell migration and immune interactions. EMBO J. 1999; 18:501-11 PubMed.

Migration related articles:

Cell Adhesion | Cytoskeleton | Regulation | Extracellular matrix & proteases | Imaging Migration Processes | Modeling Migration

Cell Adhesion

  • Cantor JM, Ginsberg MH, Rose DM. Integrin-associated proteins as potential therapeutic targets. Immunol. Rev. 2008; 223:236-51 PubMed.
  • Carman CV, Springer TA. Trans-cellular migration: cell-cell contacts get intimate. Curr. Opin. Cell Biol. 2008; 20:533-40 PubMed.
  • Karsan A. Notch and integrin affinity: a sticky situation. Sci Signal 2008; 1:pe2 PubMed.
  • Schmid RS, Maness PF. L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth. Curr. Opin. Neurobiol. 2008; 18:245-50 PubMed.
  • Trichet L, Sykes C, Plastino J. Relaxing the actin cytoskeleton for adhesion and movement with Ena/VASP. J. Cell Biol. 2008; 181:19-25 PubMed.
  • Wang H, Rudd CE. SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion. Trends Cell Biol. 2008; 18:486-93 PubMed.
  • Caswell PT, Norman JC. Integrin trafficking and the control of cell migration. Traffic 2006; 7:14-21 PubMed.
  • Kinashi T, Katagiri K. Regulation of immune cell adhesion and migration by regulator of adhesion and cell polarization enriched in lymphoid tissues. Immunology 2005; 116:164-71 PubMed.
  • Wozniak MA, Modzelewska K, Kwong L, Keely PJ. Focal adhesion regulation of cell behavior. Biochim. Biophys. Acta 2004; 1692:103-19 PubMed.
  • Miranti CK, Brugge JS. Sensing the environment: a historical perspective on integrin signal transduction. Nat. Cell Biol. 2002; 4:E83-90 PubMed.
  • Webb DJ, Parsons JT, Horwitz AF. Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again. Nat. Cell Biol. 2002; 4:E97-100 PubMed.
  • Parsons JT, Martin KH, Slack JK, Taylor JM, Weed SA. Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement. Oncogene 2000; 19:5606-13 PubMed.


  • Faix J, Breitsprecher D, Stradal TE, Rottner K. Filopodia: Complex models for simple rods. Int. J. Biochem. Cell Biol. 2009; 41:1656-64 PubMed.
  • Insall RH, Machesky LM. Actin dynamics at the leading edge: from simple machinery to complex networks. Dev. Cell 2009; 17:310-22 PubMed.
  • Vallotton P, Small JV. Shifting views on the leading role of the lamellipodium in cell migration: speckle tracking revisited. J. Cell. Sci. 2009; 122:1955-8 PubMed.
  • Fackler OT, Grosse R. Cell motility through plasma membrane blebbing. J. Cell Biol. 2008; 181:879-84 PubMed.
  • Le Clainche C, Carlier MF. Regulation of actin assembly associated with protrusion and adhesion in cell migration. Physiol. Rev. 2008; 88:489-513 PubMed.
  • Mattila PK, Lappalainen P. Filopodia: molecular architecture and cellular functions. Nat. Rev. Mol. Cell Biol. 2008; 9:446-54 PubMed.
  • Watanabe T, Noritake J, Kaibuchi K. Regulation of microtubules in cell migration. Trends Cell Biol. 2005; 15:76-83 PubMed.
  • Hall A, Nobes CD. Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2000; 355:965-70 PubMed.
  • Volkmann N, Hanein D. Actomyosin: law and order in motility. Curr. Opin. Cell Biol. 2000; 12:26-34 PubMed.
  • Serrador JM, Nieto M, Sánchez-Madrid F. Cytoskeletal rearrangement during migration and activation of T lymphocytes. Trends Cell Biol. 1999; 9:228-33 PubMed.
  • Small JV, Kaverina I, Krylyshkina O, Rottner K. Cytoskeleton cross-talk during cell motility. FEBS Lett. 1999; 452:96-9 PubMed.


  • Huveneers S, Danen EH. Adhesion signaling - crosstalk between integrins, Src and Rho. J. Cell. Sci. 2009; 122:1059-69 PubMed.
  • Kurisu S, Takenawa T. The WASP and WAVE family proteins. Genome Biol. 2009; 10:226 PubMed.
  • Grande-García A, del Pozo MA. Caveolin-1 in cell polarization and directional migration. Eur. J. Cell Biol. 2008; 87:641-7 PubMed.
  • Heasman SJ, Ridley AJ. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat. Rev. Mol. Cell Biol. 2008; 9:690-701 PubMed.
  • Kölsch V, Charest PG, Firtel RA. The regulation of cell motility and chemotaxis by phospholipid signaling. J. Cell. Sci. 2008; 121:551-9 PubMed.
  • Myers KR, Casanova JE. Regulation of actin cytoskeleton dynamics by Arf-family GTPases. Trends Cell Biol. 2008; 18:184-92 PubMed.
  • Takai Y, Miyoshi J, Ikeda W, Ogita H. Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation. Nat. Rev. Mol. Cell Biol. 2008; 9:603-15 PubMed.
  • Tiveron MC, Cremer H. CXCL12/CXCR4 signalling in neuronal cell migration. Curr. Opin. Neurobiol. 2008; 18:237-44 PubMed.
  • Valenzuela-Fernández A, Cabrero JR, Serrador JM, Sánchez-Madrid F. HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions. Trends Cell Biol. 2008; 18:291-7 PubMed.
  • Le Roy C, Wrana JL. Signaling and endocytosis: a team effort for cell migration. Dev. Cell 2005; 9:167-8 PubMed.
  • Leslie NR, Yang X, Downes CP, Weijer CJ. The regulation of cell migration by PTEN. Biochem. Soc. Trans. 2005; 33:1507-8 PubMed.
  • Poliakov A, Cotrina M, Wilkinson DG. Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly. Dev. Cell 2004; 7:465-80 PubMed.
  • Raftopoulou M, Hall A. Cell migration: Rho GTPases lead the way. Dev. Biol. 2004; 265:23-32 PubMed.
  • Chung CY, Funamoto S, Firtel RA. Signaling pathways controlling cell polarity and chemotaxis. Trends Biochem. Sci. 2001; 26:557-66 PubMed.
  • Firtel RA, Chung CY. The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients. Bioessays 2000; 22:603-15 PubMed.

Extracellular matrix & proteases

  • Leiss M, Beckmann K, Girós A, Costell M, Fässler R. The role of integrin binding sites in fibronectin matrix assembly in vivo. Curr. Opin. Cell Biol. 2008; 20:502-7 PubMed.
  • Lock JG, Wehrle-Haller B, Strömblad S. Cell-matrix adhesion complexes: master control machinery of cell migration. Semin. Cancer Biol. 2008; 18:65-76 PubMed.
  • Stylli SS, Kaye AH, Lock P. Invadopodia: at the cutting edge of tumour invasion. J Clin Neurosci 2008; 15:725-37 PubMed.
  • Berrier AL, Yamada KM. Cell-matrix adhesion. J. Cell. Physiol. 2007; 213:565-73 PubMed.
  • Even-Ram S, Yamada KM. Cell migration in 3D matrix. Curr. Opin. Cell Biol. 2005; 17:524-32 PubMed.
  • Chang C, Werb Z. The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol. 2001; 11:S37-43 PubMed.
  • Ellis V, Murphy G. Cellular strategies for proteolytic targeting during migration and invasion. FEBS Lett. 2001; 506:1-5 PubMed.
  • O'Toole EA. Extracellular matrix and keratinocyte migration. Clin. Exp. Dermatol. 2001; 26:525-30 PubMed.

Imaging Migration Processes

  • Beltman JB, Marée AF, de Boer RJ. Analysing immune cell migration. Nat. Rev. Immunol. 2009; 9:789-98 PubMed.
  • Friedl P, Gilmour D. Collective cell migration in morphogenesis, regeneration and cancer. Nat. Rev. Mol. Cell Biol. 2009; 10:445-57 PubMed.
  • Bugyi B, Le Clainche C, Romet-Lemonne G, Carlier MF. How do in vitro reconstituted actin-based motility assays provide insight into in vivo behavior?. FEBS Lett. 2008; 582:2086-92 PubMed.
  • Pittet MJ, Mempel TR. Regulation of T-cell migration and effector functions: insights from in vivo imaging studies. Immunol. Rev. 2008; 221:107-29 PubMed.
  • Worth DC, Parsons M. Adhesion dynamics: mechanisms and measurements. Int. J. Biochem. Cell Biol. 2008; 40:2397-409 PubMed.
  • Dormann D, Weijer CJ. Imaging of cell migration. EMBO J. 2006; 25:3480-93 PubMed.
  • Halin C, Rodrigo Mora J, Sumen C, von Andrian UH. In vivo imaging of lymphocyte trafficking. Annu. Rev. Cell Dev. Biol. 2005; 21:581-603 PubMed.
  • Palm D, Lang K, Brandt B, Zaenker KS, Entschladen F. In vitro and in vivo imaging of cell migration: two interdepending methods to unravel metastasis formation. Semin. Cancer Biol. 2005; 15:396-404 PubMed.

Modeling Migration

  • Rangarajan R, Zaman MH. Modeling cell migration in 3D: Status and challenges. Cell Adh Migr 2008; 2:106-9 PubMed.
  • Baker MD, Wolanin PM, Stock JB. Systems biology of bacterial chemotaxis. Curr. Opin. Microbiol. 2006; 9:187-92 PubMed.
  • Fletcher DA, Theriot JA. An introduction to cell motility for the physical scientist. Phys Biol 2004; 1:T1-10 PubMed.
  • Iglesias PA, Levchenko A. Modeling the cell's guidance system. Sci. STKE 2002; 2002:re12 PubMed.
  • Bustamante C, Keller D, Oster G. The physics of molecular motors. Acc. Chem. Res. 2001; 34:412-20 PubMed.
  • Loew LM, Schaff JC. The Virtual Cell: a software environment for computational cell biology. Trends Biotechnol. 2001; 19:401-6 PubMed.
  • Asthagiri AR, Lauffenburger DA. Bioengineering models of cell signaling. Annu Rev Biomed Eng 2000; 2:31-53 PubMed.