Cell Migration Gateway Logo

Structure - Resources

Publications - last updated February, 2016

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Calderwood DA, Campbell ID, Critchley DR. Talins and kindlins: partners in integrin-mediated adhesion. Nat. Rev. Mol. Cell Biol. 2013; 14:503-17 PubMed.
  • Cleyrat C, Darehshouri A, Anderson KL, Page C, Lidke DS, Volkmann N, Hanein D, Wilson BS. The architectural relationship of components controlling mast cell endocytosis. J. Cell. Sci. 2013; PubMed | CMC Update Article.
  • Goult BT, Xu XP, Gingras AR, Swift M, Patel B, Bate N, Kopp PM, Barsukov IL, Critchley DR, Volkmann N, Hanein D. Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: Implications for talin activation. J. Struct. Biol. 2013; PubMed | CMC Update Article.
  • Goult BT, Zacharchenko T, Bate N, Tsang R, Hey F, Gingras AR, Elliott PR, Roberts GC, Ballestrem C, Critchley DR, Barsukov IL. RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover. J. Biol. Chem. 2013; PubMed | CMC Update Article.
  • Milanesi F,, Volkmann N,, Scita G,, Hanein D. Epidermal Growth Factor Receptor Kinase Substrate 8. Encyclopedia of Signalling Molecules 2013; S. Choi (ed.): DOI.
  • Wolfenson H, Lavelin I, Geiger B. Dynamic regulation of the structure and functions of integrin adhesions. Dev. Cell 2013; 24:447-58 PubMed.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Banno A, Goult BT, Lee H, Bate N, Critchley DR, Ginsberg MH. Subcellular localization of talin is regulated by inter-domain interactions. J Biol Chem 2012; PubMed | CMC Update Article.
  • Bate N, Gingras AR, Bachir A, Horwitz R, Ye F, Patel B, Goult BT, Critchley DR. Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics. PLoS ONE 2012; 7:e34461 Full Text | CMC Update Article.
  • Delorme-Walker V, Abrivard M, Lagal V, Anderson K, Perazzi A, Gonzalez V, Page C, Chauvet J, Ochoa W, Volkmann N, Hanein D, Tardieux I. Toxofilin upregulates the host cortical actin cytoskeleton dynamics facilitating Toxoplasma invasion. J Cell Sci 2012; PubMed | CMC Update Article.
  • Janssen ME, Liu H, Volkmann N, Hanein D. The C-terminal tail domain of metavinculin, vinculin's splice variant, severs actin filaments. J Cell Biol 2012; PubMed | CMC Update Article.
  • Luxenburg C, Winograd-Katz S, Addadi L, Geiger B. Involvement of actin polymerization in podosome dynamics. J Cell Sci 2012; PubMed | CMC Update Article.
  • Shahal T, Geiger B, Dunlop IE, Spatz JP. Regulation of integrin adhesions by varying the density of substrate-bound epidermal growth factor. Biointerphases 2012; 7:23 PubMed | CMC Update Article.
  • Yates LA, Fuzery AK, Bonet R, Campbell ID, Gilbert RJ. Biophysical analysis of kindlin-3 reveals an elongated conformation and maps integrin binding to the membrane-distal β-subunit NPxY motif. J. Biol. Chem. 2012; PubMed | CMC Update Article.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Anderegg F, Geblinger D, Horvath P, Charnley M, Textor M, Addadi L, Geiger B. Substrate adhesion regulates sealing zone architecture and dynamics in cultured osteoclasts. PLoS ONE 2011; 6:e28583 PubMed.
  • Anthis NJ, Campbell ID. The tail of integrin activation. Trends Biochem Sci 2011; PubMed.
  • Collins A, Warrington A, Taylor KA, Svitkina T. Structural organization of the actin cytoskeleton at sites of clathrin-mediated endocytosis. Curr. Biol. 2011; 21:1167-75 Full Text | CMC Update Article.
  • Geblinger D, Zink C, Spencer ND, Addadi L, Geiger B. Effects of surface microtopography on the assembly of the osteoclast resorption apparatus. J R Soc Interface 2011; PubMed | CMC Update Article.
  • Geiger B, Yamada KM. Molecular Architecture and Function of Matrix Adhesions. Cold Spring Harb Perspect Biol 2011; PubMed.
  • Hanein D, Horwitz AR. The structure of cell-matrix adhesions: the new frontier. Curr Opin Cell Biol 2011; PubMed.
  • Hanein D, Volkmann N. Correlative light-electron microscopy. Adv Protein Chem Struct Biol 2011; 82:91-9 PubMed.
  • Kalli AC, Campbell ID, Sansom MS. Multiscale simulations suggest a mechanism for integrin inside-out activation. Proc. Natl. Acad. Sci. U.S.A. 2011; 108:11890-5 Full Text | CMC Update Article.
  • Prager-Khoutorsky M, Lichtenstein A, Krishnan R, Rajendran K, Mayo A, Kam Z, Geiger B, Bershadsky AD. Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing. Nat. Cell Biol. 2011; 13:1457-65 PubMed | CMC Update Article.
  • Volkmann N. Putting structure into context: fitting of atomic models into electron microscopic and electron tomographic reconstructions. Curr Opin Cell Biol 2011; PubMed.
  • Wolfenson H, Bershadsky A, Henis YI, Geiger B. Actomyosin-generated tension controls the molecular kinetics of focal adhesions. J. Cell. Sci. 2011; 124:1425-32 Full Text | CMC Update Article.
  • Xu XP, Rouiller I, Slaughter BD, Egile C, Kim E, Unruh JR, Fan X, Pollard TD, Li R, Hanein D, Volkmann N. Three-dimensional reconstructions of Arp2/3 complex with bound nucleation promoting factors. EMBO J 2011; PubMed | CMC Update Article.
  • Ye F, Kim C, Ginsberg MH. Molecular mechanism of inside-out integrin regulation. J. Thromb. Haemost. 2011; 9 Suppl 1:20-5 PubMed.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Anthis NJ, Wegener KL, Critchley DR, Campbell ID. Structural diversity in integrin/talin interactions. Structure 2010; 18:1654-66 PubMed.
  • Campbell ID. The talin FERM domain is not so FERM. Structure 2010; 18:1222-3 PubMed.
  • Elliott PR, Goult BT, Kopp PM, Bate N, Grossmann JG, Roberts GC, Critchley DR, Barsukov IL. The Structure of the talin head reveals a novel extended conformation of the FERM domain. Structure 2010; 18:1289-99 Full Text | CMC Update Article.
  • Geblinger D, Addadi L, Geiger B. Nano-topography sensing by osteoclasts. J. Cell. Sci. 2010; 123:1503-10 Full Text | CMC Update Article.
  • Goult BT, Bouaouina M, Elliott PR, Bate N, Patel B, Gingras AR, Grossmann JG, Roberts GC, Calderwood DA, Critchley DR, Barsukov IL. Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation. EMBO J. 2010; 29:1069-80 Full Text | CMC Update Article.
  • Goult BT, Gingras AR, Bate N, Barsukov IL, Critchley DR, Roberts GC. The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site. FEBS Lett. 2010; 584:2237-41 Full Text.
  • Hanein D. Tomography of actin cytoskeletal networks. Meth. Enzymol. 2010; 483:203-14 PubMed.
  • Hertzog M, Milanesi F, Hazelwood L, Disanza A, Liu H, Perlade E, Malabarba MG, Pasqualato S, Maiolica A, Confalonieri S, Le Clainche C, Offenhauser N, Block J, Rottner K, Di Fiore PP, Carlier MF, Volkmann N, Hanein D, Scita G. Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping. PLoS Biol. 2010; 8:e1000387 Full Text.
  • Kalli AC, Wegener KL, Goult BT, Anthis NJ, Campbell ID, Sansom MS. The structure of the talin/integrin complex at a lipid bilayer: an NMR and MD simulation study. Structure 2010; 18:1280-8 PubMed | CMC Update Article.
  • Medalia O, Geiger B. Frontiers of microscopy-based research into cell-matrix adhesions. Curr. Opin. Cell Biol. 2010; 22:659-68 PubMed.
  • Patla I, Volberg T, Elad N, Hirschfeld-Warneken V, Grashoff C, Fässler R, Spatz JP, Geiger B, Medalia O. Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography. Nat. Cell Biol. 2010; 12:909-15 PubMed | CMC Update Article.
  • Premkumar L, Bobkov AA, Patel M, Jaroszewski L, Bankston LA, Stec B, Vuori K, Côté JF, Liddington RC. Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs). J. Biol. Chem. 2010; 285:13211-22 Full Text | CMC Update Article.
  • Srikrishna G, Nayak J, Weigle B, Temme A, Foell D, Hazelwood L, Olsson A, Volkmann N, Hanein D, Freeze HH. Carboxylated N-glycans on RAGE promote S100A12 binding and signaling. J. Cell. Biochem. 2010; 110:645-59 Full Text.
  • Volkmann N. Methods for segmentation and interpretation of electron tomographic reconstructions. Meth. Enzymol. 2010; 483:31-46 PubMed.
  • Ye F, Hu G, Taylor D, Ratnikov B, Bobkov AA, McLean MA, Sligar SG, Taylor KA, Ginsberg MH. Recreation of the terminal events in physiological integrin activation. J. Cell Biol. 2010; 188:157-73 Full Text | CMC Update Article.
  • Zaidel-Bar R, Geiger B. The switchable integrin adhesome. J. Cell. Sci. 2010; 123:1385-8 Full Text.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Anthis NJ, Haling JR, Oxley CL, Memo M, Wegener KL, Lim CJ, Ginsberg MH, Campbell ID. Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation. J. Biol. Chem. 2009; 284:36700-10 Full Text | CMC Update Article.
  • Anthis NJ, Wegener KL, Ye F, Kim C, Goult BT, Lowe ED, Vakonakis I, Bate N, Critchley DR, Ginsberg MH, Campbell ID. The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. EMBO J. 2009; 28:3623-32 Full Text | CMC Update Article.
  • Geblinger D, Geiger B, Addadi L. Surface-induced regulation of podosome organization and dynamics in cultured osteoclasts. Chembiochem 2009; 10:158-65 Full Text | CMC Update Article.
  • Gingras AR, Ziegler WH, Bobkov AA, Joyce MG, Fasci D, Himmel M, Rothemund S, Ritter A, Grossmann JG, Patel B, Bate N, Goult BT, Emsley J, Barsukov IL, Roberts GC, Liddington RC, Ginsberg MH, Critchley DR. Structural determinants of integrin binding to the talin rod. J. Biol. Chem. 2009; 284:8866-76 Full Text.
  • Goult BT, Bate N, Anthis NJ, Wegener KL, Gingras AR, Patel B, Barsukov IL, Campbell ID, Roberts GC, Critchley DR. The structure of an interdomain complex that regulates talin activity. J. Biol. Chem. 2009; 284:15097-106 Full Text | CMC Update Article.
  • Goult BT, Bouaouina M, Harburger DS, Bate N, Patel B, Anthis NJ, Campbell ID, Calderwood DA, Barsukov IL, Roberts GC, Critchley DR. The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation. J. Mol. Biol. 2009; 394:944-56 Full Text | CMC Update Article.
  • Lee HS, Lim CJ, Puzon-McLaughlin W, Shattil SJ, Ginsberg MH. RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences. J. Biol. Chem. 2009; 284:5119-27 Full Text.
  • Volkmann N. Confidence intervals for fitting of atomic models into low-resolution densities. Acta Crystallogr. D Biol. Crystallogr. 2009; 65:679-89 Full Text.
  • Volkmann, N,, Hanein, D. Electron Microscopy in the Context of Structural Systems Biology.. In Structural Bioinformatics 2009; Bourne P and Gu J (eds). Wiley Inc., San Diego,:143-178 .
  • Winkler H, Zhu P, Liu J, Ye F, Roux KH, Taylor KA. Tomographic subvolume alignment and subvolume classification applied to myosin V and SIV envelope spikes. J. Struct. Biol. 2009; 165:64-77 Full Text.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Auer M, Koster AJ, Ziese U, Bajaj C, Volkmann N, Wang da N, Hudspeth AJ. Three-dimensional architecture of hair-bundle linkages revealed by electron-microscopic tomography. J. Assoc. Res. Otolaryngol. 2008; 9:215-24 Full Text.
  • Campbell ID. Studies of focal adhesion assembly. Biochem. Soc. Trans. 2008; 36:263-6 PubMed | CMC Update Article.
  • Garduño E, Wong-Barnum M, Volkmann N, Ellisman MH. Segmentation of electron tomographic data sets using fuzzy set theory principles. J. Struct. Biol. 2008; 162:368-79 Full Text.
  • Gingras AR, Bate N, Goult BT, Hazelwood L, Canestrelli I, Grossmann JG, Liu H, Putz NS, Roberts GC, Volkmann N, Hanein D, Barsukov IL, Critchley DR. The structure of the C-terminal actin-binding domain of talin. EMBO J. 2008; 27:458-69 Full Text | CMC Update Article.
  • Hampton CM, Liu J, Taylor DW, DeRosier DJ, Taylor KA. The 3D structure of villin as an unusual F-Actin crosslinker. Structure 2008; 16:1882-91 Full Text | CMC Update Article.
  • Leone M, Yu EC, Liddington RC, Pasquale EB, Pellecchia M. The PTB domain of tensin: NMR solution structure and phosphoinositides binding studies. Biopolymers 2008; 89:86-92 PubMed | CMC Update Article.
  • Miao L, Vanderlinde O, Liu J, Grant RP, Wouterse A, Shimabukuro K, Philipse A, Stewart M, Roberts TM. The role of filament-packing dynamics in powering amoeboid cell motility. Proc. Natl. Acad. Sci. U.S.A. 2008; 105:5390-5 Full Text.
  • Oxley CL, Anthis NJ, Lowe ED, Vakonakis I, Campbell ID, Wegener KL. An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding. J. Biol. Chem. 2008; 283:5420-6 PubMed | CMC Update Article.
  • Rouiller I, Xu XP, Amann KJ, Egile C, Nickell S, Nicastro D, Li R, Pollard TD, Volkmann N, Hanein D. The structural basis of actin filament branching by the Arp2/3 complex. J. Cell Biol. 2008; 180:887-95 Full Text | CMC Update Article.
  • Wegener KL, Basran J, Bagshaw CR, Campbell ID, Roberts GC, Critchley DR, Barsukov IL. Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain. J. Mol. Biol. 2008; 382:112-26 PubMed.
  • Wegener KL, Campbell ID. Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (review). Mol. Membr. Biol. 2008; 25:376-87 Full Text | CMC Update Article.
  • Ye F, Liu J, Winkler H, Taylor KA. Integrin alpha IIb beta 3 in a membrane environment remains the same height after Mn2+ activation when observed by cryoelectron tomography. J. Mol. Biol. 2008; 378:976-86 Full Text | CMC Update Article.
  • Zamir E, Geiger B, Kam Z. Quantitative multicolor compositional imaging resolves molecular domains in cell-matrix adhesions. PLoS ONE 2008; 3:e1901 Full Text | CMC Update Article.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Applewhite DA, Barzik M, Kojima S, Svitkina TM, Gertler FB, Borisy GG. Ena/VASP proteins have an anti-capping independent function in filopodia formation. Mol. Biol. Cell 2007; 18:2579-91 Full Text.
  • Delorme V, Machacek M, DerMardirossian C, Anderson KL, Wittmann T, Hanein D, Waterman-Storer C, Danuser G, Bokoch GM. Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks. Dev. Cell 2007; 13:646-62 Full Text | CMC Update Article.
  • Hampton CM, Taylor DW, Taylor KA. Novel structures for alpha-actinin:F-actin interactions and their implications for actin-membrane attachment and tension sensing in the cytoskeleton. J. Mol. Biol. 2007; 368:92-104 Full Text | CMC Update Article.
  • Lad Y, Kiema T, Jiang P, Pentikäinen OT, Coles CH, Campbell ID, Calderwood DA, Ylänne J. Structure of three tandem filamin domains reveals auto-inhibition of ligand binding. EMBO J. 2007; 26:3993-4004 Full Text.
  • Lowey S, Saraswat LD, Liu H, Volkmann N, Hanein D. Evidence for an interaction between the SH3 domain and the N-terminal extension of the essential light chain in class II myosins. J. Mol. Biol. 2007; 371:902-13 Full Text.
  • Luxenburg C, Geblinger D, Klein E, Anderson K, Hanein D, Geiger B, Addadi L. The architecture of the adhesive apparatus of cultured osteoclasts: from podosome formation to sealing zone assembly. PLoS ONE 2007; 2:e179 Full Text | CMC Update Article.
  • McCleverty CJ, Lin DC, Liddington RC. Structure of the PTB domain of tensin1 and a model for its recruitment to fibrillar adhesions. Protein Sci. 2007; 16:1223-9 Full Text | CMC Update Article.
  • Petrich BG, Fogelstrand P, Partridge AW, Yousefi N, Ablooglu AJ, Shattil SJ, Ginsberg MH. The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation. J. Clin. Invest. 2007; 117:2250-9 Full Text | CMC Update Article.
  • Petrich BG, Marchese P, Ruggeri ZM, Spiess S, Weichert RA, Ye F, Tiedt R, Skoda RC, Monkley SJ, Critchley DR, Ginsberg MH. Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J. Exp. Med. 2007; 204:3103-11 Full Text | CMC Update Article.
  • Prager GW, Féral CC, Kim C, Han J, Ginsberg MH. CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling. J. Biol. Chem. 2007; 282:24477-84 PubMed.
  • Shacham E, Sheehan B, Volkmann N. Density-based score for selecting near-native atomic models of unknown structures. J. Struct. Biol. 2007; 158:188-95 Full Text.
  • Taylor DW, Kelly DF, Cheng A, Taylor KA. On the freezing and identification of lipid monolayer 2-D arrays for cryoelectron microscopy. J. Struct. Biol. 2007; 160:305-12 Full Text | CMC Update Article.
  • Trybus KM, Gushchin MI, Lui H, Hazelwood L, Krementsova EB, Volkmann N, Hanein D. Effect of calcium on calmodulin bound to the IQ motifs of myosin V. J. Biol. Chem. 2007; 282:23316-25 PubMed.
  • van der Heide P, Xu XP, Marsh BJ, Hanein D, Volkmann N. Efficient automatic noise reduction of electron tomographic reconstructions based on iterative median filtering. J. Struct. Biol. 2007; 158:196-204 PubMed | CMC Update Article.
  • Volkmann N, Lui H, Hazelwood L, Trybus KM, Lowey S, Hanein D. The R403Q myosin mutation implicated in familial hypertrophic cardiomyopathy causes disorder at the actomyosin interface. PLoS ONE 2007; 2:e1123 Full Text.
  • Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, Ginsberg MH, Campbell ID. Structural basis of integrin activation by talin. Cell 2007; 128:171-82 PubMed | CMC Update Article.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Gingras AR, Vogel KP, Steinhoff HJ, Ziegler WH, Patel B, Emsley J, Critchley DR, Roberts GC, Barsukov IL. Structural and dynamic characterization of a vinculin binding site in the talin rod. Biochemistry 2006; 45:1805-17 PubMed.
  • Harris ES, Rouiller I, Hanein D, Higgs HN. Mechanistic differences in actin bundling activity of two mammalian formins, FRL1 and mDia2. J. Biol. Chem. 2006; 281:14383-92 PubMed.
  • Iber D, Campbell ID. Integrin activation--the importance of a positive feedback. Bull. Math. Biol. 2006; 68:945-56 PubMed.
  • Janssen ME, Kim E, Liu H, Fujimoto LM, Bobkov A, Volkmann N, Hanein D. Three-dimensional structure of vinculin bound to actin filaments. Mol. Cell 2006; 21:271-81 PubMed | CMC Update Article.
  • Kelly DF, Taylor DW, Bakolitsa C, Bobkov AA, Bankston L, Liddington RC, Taylor KA. Structure of the alpha-actinin-vinculin head domain complex determined by cryo-electron microscopy. J. Mol. Biol. 2006; 357:562-73 PubMed.
  • Kiema T, Lad Y, Jiang P, Oxley CL, Baldassarre M, Wegener KL, Campbell ID, Ylänne J, Calderwood DA. The molecular basis of filamin binding to integrins and competition with talin. Mol. Cell 2006; 21:337-47 PubMed | CMC Update Article.
  • Liu J, Taylor DW, Krementsova EB, Trybus KM, Taylor KA. Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography. Nature 2006; 442:208-11 PubMed | CMC Update Article.
  • Luxenburg C, Addadi L, Geiger B. The molecular dynamics of osteoclast adhesions. Eur. J. Cell Biol. 2006; 85:203-11 PubMed | CMC Update Article.
  • Luxenburg C, Parsons JT, Addadi L, Geiger B. Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts. J. Cell. Sci. 2006; 119:4878-88 PubMed | CMC Update Article.
  • Patel B, Gingras AR, Bobkov AA, Fujimoto LM, Zhang M, Liddington RC, Mazzeo D, Emsley J, Roberts GC, Barsukov IL, Critchley DR. The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod. J. Biol. Chem. 2006; 281:7458-67 PubMed.
  • Saunders RM, Holt MR, Jennings L, Sutton DH, Barsukov IL, Bobkov A, Liddington RC, Adamson EA, Dunn GA, Critchley DR. Role of vinculin in regulating focal adhesion turnover. Eur. J. Cell Biol. 2006; 85:487-500 PubMed.
  • Winkler H, Taylor KA. Accurate marker-free alignment with simultaneous geometry determination and reconstruction of tilt series in electron tomography. Ultramicroscopy 2006; 106:240-54 PubMed.
  • Ziegler WH, Liddington RC, Critchley DR. The structure and regulation of vinculin. Trends Cell Biol. 2006; 16:453-60 PubMed | CMC Update Article.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Barzik M, Kotova TI, Higgs HN, Hazelwood L, Hanein D, Gertler FB, Schafer DA. Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. J. Biol. Chem. 2005; 280:28653-62 Full Text.
  • de Pereda JM, Wegener KL, Santelli E, Bate N, Ginsberg MH, Critchley DR, Campbell ID, Liddington RC. Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions. J. Biol. Chem. 2005; 280:8381-6 PubMed | CMC Update Article.
  • Egile C, Rouiller I, Xu XP, Volkmann N, Li R, Hanein D. Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions. PLoS Biol. 2005; 3:e383 Full Text | CMC Update Article.
  • Feral CC, Nishiya N, Fenczik CA, Stuhlmann H, Slepak M, Ginsberg MH. CD98hc (SLC3A2) mediates integrin signaling. Proc. Natl. Acad. Sci. U.S.A. 2005; 102:355-60 Full Text.
  • Gingras AR, Ziegler WH, Frank R, Barsukov IL, Roberts GC, Critchley DR, Emsley J. Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod. J. Biol. Chem. 2005; 280:37217-24 PubMed.
  • Gupton SL, Anderson KL, Kole TP, Fischer RS, Ponti A, Hitchcock-DeGregori SE, Danuser G, Fowler VM, Wirtz D, Hanein D, Waterman-Storer CM. Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin. J. Cell Biol. 2005; 168:619-31 Full Text | CMC Update Article.
  • Kelly DF, Taylor KA. Identification of the beta1-integrin binding site on alpha-actinin by cryoelectron microscopy. J. Struct. Biol. 2005; 149:290-302 PubMed | CMC Update Article.
  • Martin AC, Xu XP, Rouiller I, Kaksonen M, Sun Y, Belmont L, Volkmann N, Hanein D, Welch M, Drubin DG. Effects of Arp2 and Arp3 nucleotide-binding pocket mutations on Arp2/3 complex function. J. Cell Biol. 2005; 168:315-28 Full Text | CMC Update Article.
  • Volkmann N, Liu H, Hazelwood L, Krementsova EB, Lowey S, Trybus KM, Hanein D. The structural basis of myosin V processive movement as revealed by electron cryomicroscopy. Mol. Cell 2005; 19:595-605 PubMed | CMC Update Article.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Bakolitsa C, Cohen DM, Bankston LA, Bobkov AA, Cadwell GW, Jennings L, Critchley DR, Craig SW, Liddington RC. Structural basis for vinculin activation at sites of cell adhesion. Nature 2004; 430:583-6 PubMed | CMC Update Article.
  • Biyasheva A, Svitkina T, Kunda P, Baum B, Borisy G. Cascade pathway of filopodia formation downstream of SCAR. J. Cell. Sci. 2004; 117:837-48 PubMed.
  • Calderwood DA, Tai V, Di Paolo G, De Camilli P, Ginsberg MH. Competition for talin results in trans-dominant inhibition of integrin activation. J. Biol. Chem. 2004; 279:28889-95 PubMed.
  • Campbell ID, Ginsberg MH. The talin-tail interaction places integrin activation on FERM ground. Trends Biochem. Sci. 2004; 29:429-35 PubMed.
  • Jeng RL, Goley ED, D'Alessio JA, Chaga OY, Svitkina TM, Borisy GG, Heinzen RA, Welch MD. A Rickettsia WASP-like protein activates the Arp2/3 complex and mediates actin-based motility. Cell. Microbiol. 2004; 6:761-9 PubMed.
  • Kloeker S, Major MB, Calderwood DA, Ginsberg MH, Jones DA, Beckerle MC. The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J. Biol. Chem. 2004; 279:6824-33 PubMed.
  • Lebrand C, Dent EW, Strasser GA, Lanier LM, Krause M, Svitkina TM, Borisy GG, Gertler FB. Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1. Neuron 2004; 42:37-49 PubMed.
  • Lee HS, Bellin RM, Walker DL, Patel B, Powers P, Liu H, Garcia-Alvarez B, de Pereda JM, Liddington RC, Volkmann N, Hanein D, Critchley DR, Robson RM. Characterization of an actin-binding site within the talin FERM domain. J. Mol. Biol. 2004; 343:771-84 PubMed.
  • Liu J, Taylor DW, Taylor KA. A 3-D reconstruction of smooth muscle alpha-actinin by CryoEm reveals two different conformations at the actin-binding region. J. Mol. Biol. 2004; 338:115-25 PubMed.
  • Mejillano MR, Kojima S, Applewhite DA, Gertler FB, Svitkina TM, Borisy GG. Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Cell 2004; 118:363-73 PubMed.
  • Volkmann N. An approach to automated particle picking from electron micrographs based on reduced representation templates. J. Struct. Biol. 2004; 145:152-6 PubMed.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Arias-Salgado EG, Lizano S, Sarkar S, Brugge JS, Ginsberg MH, Shattil SJ. Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc. Natl. Acad. Sci. U.S.A. 2003; 100:13298-302 Full Text.
  • Calderwood DA, Fujioka Y, de Pereda JM, García-Alvarez B, Nakamoto T, Margolis B, McGlade CJ, Liddington RC, Ginsberg MH. Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc. Natl. Acad. Sci. U.S.A. 2003; 100:2272-7 Full Text.
  • Calderwood DA, Ginsberg MH. Talin forges the links between integrins and actin. Nat. Cell Biol. 2003; 5:694-7 PubMed.
  • García-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC. Structural determinants of integrin recognition by talin. Mol. Cell 2003; 11:49-58 PubMed.
  • Goldfinger LE, Han J, Kiosses WB, Howe AK, Ginsberg MH. Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration. J. Cell Biol. 2003; 162:731-41 Full Text.
  • Hansen M, Prior IA, Hughes PE, Oertli B, Chou FL, Willumsen BM, Hancock JF, Ginsberg MH. C-terminal sequences in R-Ras are involved in integrin regulation and in plasma membrane microdomain distribution. Biochem. Biophys. Res. Commun. 2003; 311:829-38 PubMed.
  • Kinbara K, Goldfinger LE, Hansen M, Chou FL, Ginsberg MH. Ras GTPases: integrins' friends or foes?. Nat. Rev. Mol. Cell Biol. 2003; 4:767-76 PubMed.
  • Liddington RC, Bankston LA, de Pereda JM. Cell adhesion: a FERM grasp of membrane dynamics. Curr. Biol. 2003; 13:R94-5 PubMed.
  • Pollard TD, Borisy GG. Cellular motility driven by assembly and disassembly of actin filaments. Cell 2003; 112:453-65 PubMed.
  • Svitkina TM, Bulanova EA, Chaga OY, Vignjevic DM, Kojima S, Vasiliev JM, Borisy GG. Mechanism of filopodia initiation by reorganization of a dendritic network. J. Cell Biol. 2003; 160:409-21 Full Text.
  • Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, de Pereda JM, Ginsberg MH, Calderwood DA. Talin binding to integrin beta tails: a final common step in integrin activation. Science 2003; 302:103-6 PubMed.
  • Ulmer TS, Calderwood DA, Ginsberg MH, Campbell ID. Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit. Biochemistry 2003; 42:8307-12 PubMed.
  • Verkhovsky AB, Chaga OY, Schaub S, Svitkina TM, Meister JJ, Borisy GG. Orientational order of the lamellipodial actin network as demonstrated in living motile cells. Mol. Biol. Cell 2003; 14:4667-75 Full Text.
  • Vignjevic D, Yarar D, Welch MD, Peloquin J, Svitkina T, Borisy GG. Formation of filopodia-like bundles in vitro from a dendritic network. J. Cell Biol. 2003; 160:951-62 Full Text.
  • Volkmann N, Hanein D. Docking of atomic models into reconstructions from electron microscopy. Meth. Enzymol. 2003; 374:204-25 PubMed.
  • Volkmann N, Hanein D. Electron microscopy. Methods Biochem Anal 2003; 44:115-33 PubMed.
  • Volkmann N, Ouyang G, Trybus KM, DeRosier DJ, Lowey S, Hanein D. Myosin isoforms show unique conformations in the actin-bound state. Proc. Natl. Acad. Sci. U.S.A. 2003; 100:3227-32 Full Text.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Bear JE, Svitkina TM, Krause M, Schafer DA, Loureiro JJ, Strasser GA, Maly IV, Chaga OY, Cooper JA, Borisy GG, Gertler FB. Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell 2002; 109:509-21 PubMed.
  • Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, Liddington RC, Ginsberg MH. The phosphotyrosine binding-like domain of talin activates integrins. J. Biol. Chem. 2002; 277:21749-58 PubMed.
  • Hayashi I, Vuori K, Liddington RC. The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin. Nat. Struct. Biol. 2002; 9:101-6 PubMed.
  • Liddington RC, Ginsberg MH. Integrin activation takes shape. J. Cell Biol. 2002; 158:833-9 Full Text | CMC Update Article.
  • Volkmann N. A novel three-dimensional variant of the watershed transform for segmentation of electron density maps. J. Struct. Biol. 2002; 138:123-9 PubMed.
  • Woodside DG, Obergfell A, Talapatra A, Calderwood DA, Shattil SJ, Ginsberg MH. The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains. J. Biol. Chem. 2002; 277:39401-8 PubMed.
return to top

Software

Volkmann Lab

  • Click here to go to the CoAn site, which provides a framework designed to facilitate data analysis. It currently consists of a collection of command-line executables, each of which performs a relatively simple task. These can be strung together in various ways to allow a certain type of analysis such as segmentation, denoising, or docking of atomic models into a density. Some of these packages are available for public download:

return to top
return to top