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Transgenic and Knockout Mouse - Resources

Publications - last updated August, 2008

  • Dent EW, Kwiatkowski AV, Mebane LM, Philippar U, Barzik M, Rubinson DA, Gupton S, Van Veen JE, Furman C, Zhang J, Alberts AS, Mori S, Gertler FB. Filopodia are required for cortical neurite initiation. Nat Cell Biol 2007; 9 (12):1347-59 PubMed
  • Kwiatkowski AV, Rubinson DA, Dent EW, van Veen .E, Leslie JD, Zhang J, Mebane LM, Philippar U, Pinheiro EM, Burds AA, Bronson RT, Mori S, Fässler R, Gertler FB. Ena/VASP is required for neuritogenesis in the developing cortex. Neuron 2007; 56 (3):441-55 PubMed | CMC Update article.
  • Petrich BG, Fogelstrand P, Partridge AW, Yousefi N, Ablooglu AJ, Shattil SJ, Ginsberg MH. The antithrombotic potential of selective blockade of talin-dependent integrin alpha(IIb)beta(3) (platelet GPIIb-IIIa) activation. J Clin Invest. 2007; 117(8):2250-9. PubMed | CMC Update article.
  • Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, Rooney DL, Ihrig MM, McManus MT, Gertler FB, Scott ML, Van Parijs L. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet. 2003 Mar;33(3):401-6. Epub 2003; 33 (3):401-6.
    Corrigendum "The authors wish to remove panels b, d and e of Figure 2 because they were falsified or fabricated. This correction follows an investigation by the Massachusetts Institute of Technology into scientific misconduct by Luk Van Parijs, the communicating author of the paper. " Nat Genet. 2007 39(6): 803. PubMed
  • Yoshioka J, Imahashi K, Gabel SA, Chutkow WA, Burds AA, Gannon J, Schulze PC, MacGillivray C, London RE, Murphy E, Lee RT. Targeted Deletion of Thioredoxin-Interacting Protein Regulates Cardiac Dysfunction in Response to Pressure Overload. Circ Res 2007; 101 (12):1328-38. PubMed

Methods

Links

  • Much of the information on this page was written by Aurora Burds Connor, manager of the Transgenic facility at MIT. For more details on the facility please visit their website.
  • The Knockout Mouse Project (KOMP), a trans-NIH initiative to generate a public resource of mouse embryonic stem (ES) cells containing a null mutation in every gene in the mouse genome, accepts nominations for genes to knock out.
  • Knockout Mice fact sheet at the NIH National Human Genome Research Institute.
  • The Trans-NIH Mouse Initiatives have listed the readily-available knockout mice and information on their phenotypes.  These include mice in the collections of the Mutant Mouse Regional Resource Center (MMRRC), and Jackson Labs (JAX).
  • Nagy Lab Web site - information about ES cells and the definitive Cre mouse database.
  • Microarray and Genomics Core Facility - BAC Libraries, use the RPCI-22 Mouse 129 library filters and order the positive clones to make your targeting vector.
  • The Gene Expression Nervous System Atlas - Gensat database contains a gene expression atlas of the central nervous system of the mouse based on bacterial artificial chromosomes (BACs).
  • Knockout mice generated by Gensat (and many other projects) are being transferred to Mutant Mouse Regional Resource Centers (MMRRC) for distribution. The purpose of the MMRRC is to ensure the continued availability of scientifically valuable, genetically engineered mice and to distribute these mice to qualified researchers studying human and animal biology and disease.
  • BioMedNet has generated a Mouse Knockout and Mutation Database. Registration is free, and the database provides phenotypic information, links to publications and contact information for acquiring the mouse of interest.
  • The International Gene Trap Consortium is a subgroup of the International Mouse Mutagenesis Consortium and provides an international resource of embryonic stem cells with gene trap insertions in every or most genes in the mouse genome.
  • The International Mouse Strain Resource (IMSR) is a searchable online database of mouse strains and stocks available worldwide, including inbred, mutant, and genetically engineered mice.
  • The Federation of International Mouse Resources (FIMRe) is a collaborating group of Mouse Repository and Resource Centers worldwide whose collective goal is to archive and provide strains of mice as cryopreserved embryos and gametes, ES cell lines, and live breeding stock to the research community.