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Discovery - Resources

Publications - last updated February, 2016

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Wolfenson H, Lavelin I, Geiger B. Dynamic regulation of the structure and functions of integrin adhesions. Dev. Cell 2013; 24:447-58 PubMed.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Guo Q, Wang X, Tibbitt MW, Anseth KS, Montell DJ, Elisseeff JH. Light activated cell migration in synthetic extracellular matrices. Biomaterials 2012; 33:8040-6 PubMed | CMC Update Article.
  • Luxenburg C, Winograd-Katz S, Addadi L, Geiger B. Involvement of actin polymerization in podosome dynamics. J Cell Sci 2012; PubMed | CMC Update Article.
  • Martynovsky M, Wong MC, Byrd DT, Kimble J, Schwarzbauer JE. mig-38, a novel gene that regulates distal tip cell turning during gonadogenesis in C. elegans hermaphrodites. Dev. Biol. 2012; 368:404-14 PubMed | CMC Update Article.
  • Mouneimne G, Hansen SD, Selfors LM, Petrak L, Hickey MM, Gallegos LL, Simpson KJ, Lim J, Gertler FB, Hartwig JH, Mullins RD, Brugge JS. Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion. Cancer Cell 2012; 22:615-30 Full Text | CMC Update Article.
  • Ng MR, Besser A, Danuser G, Brugge JS. Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility. J. Cell Biol. 2012; 199:545-63 PubMed | CMC Update Article.
  • Shahal T, Geiger B, Dunlop IE, Spatz JP. Regulation of integrin adhesions by varying the density of substrate-bound epidermal growth factor. Biointerphases 2012; 7:23 PubMed | CMC Update Article.
  • Wong MC, Schwarzbauer JE. Gonad morphogenesis and distal tip cell migration in the Caenorhabditis elegans hermaphrodite. Wiley Interdiscip Rev Dev Biol 2012; 1:519-531 Full Text.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Anderegg F, Geblinger D, Horvath P, Charnley M, Textor M, Addadi L, Geiger B. Substrate adhesion regulates sealing zone architecture and dynamics in cultured osteoclasts. PLoS ONE 2011; 6:e28583 PubMed.
  • Gallegos L, Ng MR, Brugge JS. The myosin-II-responsive focal adhesion proteome: a tour de force?. Nat. Cell Biol. 2011; PubMed.
  • Geblinger D, Zink C, Spencer ND, Addadi L, Geiger B. Effects of surface microtopography on the assembly of the osteoclast resorption apparatus. J R Soc Interface 2011; PubMed | CMC Update Article.
  • Geiger B, Yamada KM. Molecular Architecture and Function of Matrix Adhesions. Cold Spring Harb Perspect Biol 2011; PubMed.
  • He L, Wang X, Montell DJ. Shining light on Drosophila oogenesis: live imaging of egg development. Curr Opin Genet Dev 2011; PubMed.
  • Iwanicki MP, Davidowitz RA, Ng MR, Besser A, Muranen T, Merritt M, Danuser G, Ince TA, Ince T, Brugge JS. Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. Cancer Discov 2011; 1:144-57 Full Text.
  • Kim JH, Cho A, Yin H, Schafer DA, Mouneimne G, Simpson KJ, Nguyen KV, Brugge JS, Montell DJ. Psidin, a conserved protein that regulates protrusion dynamics and cell migration. Genes Dev. 2011; 25:730-41 PubMed | CMC Update Article.
  • Prager-Khoutorsky M, Lichtenstein A, Krishnan R, Rajendran K, Mayo A, Kam Z, Geiger B, Bershadsky AD. Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing. Nat. Cell Biol. 2011; 13:1457-65 PubMed | CMC Update Article.
  • Prasad M, Wang X, He L, Montell DJ. Border cell migration: a model system for live imaging and genetic analysis of collective cell movement. Methods Mol. Biol. 2011; 769:277-86 PubMed.
  • Winograd-Katz SE, Brunner MC, Mirlas N, Geiger B. Analysis of the signaling pathways regulating Src-dependent remodeling of the actin cytoskeleton. Eur. J. Cell Biol. 2011; 90:143-56 Full Text.
  • Wolfenson H, Bershadsky A, Henis YI, Geiger B. Actomyosin-generated tension controls the molecular kinetics of focal adhesions. J. Cell. Sci. 2011; 124:1425-32 Full Text | CMC Update Article.
  • Wong MC, Martynovsky M, Schwarzbauer JE. Analysis of cell migration using Caenorhabditis elegans as a model system. Methods Mol. Biol. 2011; 769:233-47 PubMed.
  • Wu YI, Wang X, He L, Montell D, Hahn KM. Spatiotemporal Control of Small GTPases with Light Using the LOV Domain. Meth. Enzymol. 2011; 497:393-407 PubMed | CMC Update Article.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • D'Ambrosio MV, Vale RD. A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis. J. Cell Biol. 2010; 191:471-8 Full Text | CMC Update Article.
  • He L, Wang X, Tang HL, Montell DJ. Tissue elongation requires oscillating contractions of a basal actomyosin network. Nat. Cell Biol. 2010; 12:1133-42 PubMed | CMC Update Article.
  • Mann M, Barad O, Agami R, Geiger B, Hornstein E. miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate. Proc. Natl. Acad. Sci. U.S.A. 2010; 107:15804-9 Full Text.
  • Ou G, Stuurman N, D'Ambrosio M, Vale RD. Polarized myosin produces unequal-size daughters during asymmetric cell division. Science 2010; 330:677-80 Full Text.
  • Patla I, Volberg T, Elad N, Hirschfeld-Warneken V, Grashoff C, Fässler R, Spatz JP, Geiger B, Medalia O. Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography. Nat. Cell Biol. 2010; 12:909-15 PubMed | CMC Update Article.
  • Wang X, He L, Wu YI, Hahn KM, Montell DJ. Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo. Nat. Cell Biol. 2010; 12:591-7 Full Text.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Muller PA, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S, Lukashchuk N, Gillespie DA, Ludwig RL, Gosselin P, Cromer A, Brugge JS, Sansom OJ, Norman JC, Vousden KH. Mutant p53 drives invasion by promoting integrin recycling. Cell 2009; 139:1327-41 PubMed.
  • Ou G, Vale RD. Molecular signatures of cell migration in C. elegans Q neuroblasts. J. Cell Biol. 2009; 185:77-85 Full Text.
  • Winograd-Katz SE, Itzkovitz S, Kam Z, Geiger B. Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown. J. Cell Biol. 2009; 186:423-36 Full Text | CMC Update Article.
  • Wolfenson H, Henis YI, Geiger B, Bershadsky AD. The heel and toe of the cell's foot: a multifaceted approach for understanding the structure and dynamics of focal adhesions. Cell Motil. Cytoskeleton 2009; 66:1017-29 Full Text.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Cram, EJ, Schwarzbauer, JE. RNAi vector feeding protocol for distal tip cell migration studies in C. Elegans.. Nature Protocols (on line) 2008; DOI: 10.1038/nprot.2008.27:. DOI.
  • Meighan CM, Schwarzbauer JE. Temporal and spatial regulation of integrins during development. Curr. Opin. Cell Biol. 2008; 20:520-4 Full Text.
  • Melani M, Simpson KJ, Brugge JS, Montell D. Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1. Curr. Biol. 2008; 18:532-7 PubMed | CMC Update Article.
  • Nadav L, Kalchenko V, Barak MM, Naparstek E, Geiger B, Katz BZ. Tumorigenic potential and disease manifestations of malignant B-cell variants differing in their fibronectin adhesiveness. Exp. Hematol. 2008; 36:1524-34 Full Text.
  • Naffar-Abu-Amara S, Shay T, Galun M, Cohen N, Isakoff SJ, Kam Z, Geiger B. Identification of novel pro-migratory, cancer-associated genes using quantitative, microscopy-based screening. PLoS ONE 2008; 3:e1457 Full Text | CMC Update Article.
  • Simpson KJ, Selfors LM, Bui J, Reynolds A, Leake D, Khvorova A, Brugge JS. Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nat. Cell Biol. 2008; PubMed | CMC Update Article.
  • Wang, X, Starz-Gaiano, M, Bridges, T, Montell, D. Purification of specific cell populations from Drosophila tissues by magnetic bead sorting, for use in gene expression profiling. Nature Protocols (on line) 2008; doi: 10.1038/nprot.2008.28: DOI.
  • Zamir E, Geiger B, Kam Z. Quantitative multicolor compositional imaging resolves molecular domains in cell-matrix adhesions. PLoS ONE 2008; 3:e1901 Full Text | CMC Update Article.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Luxenburg C, Geblinger D, Klein E, Anderson K, Hanein D, Geiger B, Addadi L. The architecture of the adhesive apparatus of cultured osteoclasts: from podosome formation to sealing zone assembly. PLoS ONE 2007; 2:e179 Full Text | CMC Update Article.
  • Paran Y, Ilan M, Kashman Y, Goldstein S, Liron Y, Geiger B, Kam Z. High-throughput screening of cellular features using high-resolution light-microscopy; application for profiling drug effects on cell adhesion. J. Struct. Biol. 2007; 158:233-43 PubMed.
  • Prasad, M, Jang, AC-C, Montell, DJ. A protocol for culturing Drosophila melanogaster egg chambers for live imaging. Nature Protocols (on line) 2007; doi: 10.1038/nprot.2007.233: DOI.
  • Wang X, Adam JC, Montell D. Spatially localized Kuzbanian required for specific activation of Notch during border cell migration. Dev. Biol. 2007; 301:532-40 PubMed | CMC Update Article.
  • Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat. Cell Biol. 2007; 9:858-67 Full Text | CMC Update Article.
  • Zaidel-Bar R, Milo R, Kam Z, Geiger B. A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions. J. Cell. Sci. 2007; 120:137-48 PubMed | CMC Update Article.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Abu-Abied M, Golomb L, Belausov E, Huang S, Geiger B, Kam Z, Staiger CJ, Sadot E. Identification of plant cytoskeleton-interacting proteins by screening for actin stress fiber association in mammalian fibroblasts. Plant J. 2006; 48:367-79 PubMed.
  • Bershadsky A, Kozlov M, Geiger B. Adhesion-mediated mechanosensitivity: a time to experiment, and a time to theorize. Curr. Opin. Cell Biol. 2006; 18:472-81 PubMed.
  • Cram EJ, Shang H, Schwarzbauer JE. A systematic RNA interference screen reveals a cell migration gene network in C. elegans. J. Cell. Sci. 2006; 119:4811-8 PubMed | CMC Update Article.
  • Montell DJ. The social lives of migrating cells in Drosophila. Curr. Opin. Genet. Dev. 2006; 16:374-83 PubMed | CMC Update Article.
  • Paran Y, Lavelin I, Naffar-Abu-Amara S, Winograd-Katz S, Liron Y, Geiger B, Kam Z. Development and application of automatic high-resolution light microscopy for cell-based screens. Meth. Enzymol. 2006; 414:228-47 PubMed | CMC Update Article.
  • Wang X, Bo J, Bridges T, Dugan KD, Pan TC, Chodosh LA, Montell DJ. Analysis of cell migration using whole-genome expression profiling of migratory cells in the Drosophila ovary. Dev. Cell 2006; 10:483-95 PubMed | CMC Update Article.
  • Witt AE, Hines LM, Collins NL, Hu Y, Gunawardane RN, Moreira D, Raphael J, Jepson D, Koundinya M, Rolfs A, Taron B, Isakoff SJ, Brugge JS, LaBaer J. Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer. J. Proteome Res. 2006; 5:599-610 Full Text | CMC Update Article.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Gunawardane RN, Sgroi DC, Wrobel CN, Koh E, Daley GQ, Brugge JS. Novel role for PDEF in epithelial cell migration and invasion. Cancer Res. 2005; 65:11572-80 Full Text | CMC Update Article.
  • Lavelin I, Geiger B. Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton. J. Biol. Chem. 2005; 280:7178-85 PubMed.
  • McDonald JA, Montell DJ. Analysis of cell migration using Drosophila as a model system. Methods Mol. Biol. 2005; 294:175-202 PubMed.
  • Shemesh T, Geiger B, Bershadsky AD, Kozlov MM. Focal adhesions as mechanosensors: a physical mechanism. Proc. Natl. Acad. Sci. U.S.A. 2005; 102:12383-8 Full Text | CMC Update Article.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Seton-Rogers SE, Lu Y, Hines LM, Koundinya M, LaBaer J, Muthuswamy SK, Brugge JS. Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 2004; 101:1257-62 Full Text.
  • Webb DJ, Donais K, Whitmore LA, Thomas SM, Turner CE, Parsons JT, Horwitz AF. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat. Cell Biol. 2004; 6:154-61 PubMed.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Arias-Salgado EG, Lizano S, Sarkar S, Brugge JS, Ginsberg MH, Shattil SJ. Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc. Natl. Acad. Sci. U.S.A. 2003; 100:13298-302 Full Text.
  • Montell DJ. Border-cell migration: the race is on. Nat. Rev. Mol. Cell Biol. 2003; 4:13-24 PubMed.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

  • Ambroise Y, Yaspan B, Ginsberg MH, Boger DL. Inhibitors of cell migration that inhibit intracellular paxillin/alpha4 binding: a well-documented use of positional scanning libraries. Chem. Biol. 2002; 9:1219-26 PubMed.
  • Manabe R, Kovalenko M, Webb DJ, Horwitz AR. GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration. J. Cell. Sci. 2002; 115:1497-510 PubMed.
  • Manabe R, Whitmore L, Weiss JM, Horwitz AR. Identification of a novel microtubule-associated protein that regulates microtubule organization and cytokinesis by using a GFP-screening strategy. Curr. Biol. 2002; 12:1946-51 PubMed | CMC Update Article.
  • Mandell JW, Manabe R, Horwitz AF, Baumgart JP. Fluorescence imaging of mobility shifts: an expression cloning method for identification of cell signaling targets. Lab. Invest. 2002; 82:1631-6 PubMed.
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Software

Geiger Lab

  • The Geiger laboratory has developed high throughput imaging approached, the hardware and software requirements of which are described here.
  • WIS-PhagoTracker; a powerful new software tool, developed by Ofra Golani, Meirav Galun and Suha Naffar Abu-Amara in the laboratories of Prof. Benny Geiger and Prof. Ronen Basri at the Department of Molecular Cell Biology and the Department of Computer Science and Applied Mathematics and Weizmann Institute of Science for quantitative analysis of cell migration, is available free for academic usage.
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