Gene Screens
Genes identified from the MCF-7 cDNA library that increase migratory behavior in MCF-10A cells as detected using the transwell migration assay.
For more details on the screen and PDEF, see the following: Gunawardane R. N., Sgroi D. C., Wrobel C. N., Koh E., Daley G. Q., and Brugge J.S. , A novel role for PDEF in epithelial cell migration and invasion. Cancer Res. 65(24):11572-80. (2005) PubMed.
If you have any questions related to this data please contact Dr. Joan Brugge
| Protein | Protein Class | Phenotype |
|---|---|---|
| RAN | small GTPase | ++ |
| GADD45B (GADD45) | cell cycle regulator | + |
| GLTSCR2 | unknown | + |
Phenotype Legend
| + | 2-> 3 fold over control |
| ++ | 3 --> 10 fold over control |
| +++ | 10-50 fold over control |
| ++++ | > 50 fold over control |