Subject archive
2008 Signalling
Wnt5a Control of Cell Polarity and Directional Movement by Polarized Redistribution of Adhesion Receptors
Witze, E. S. et al.
ScienceScience 320 320
(18 April 2008); doi: 10.1126/science.1151250Endocytic transport of integrins during cell migration and invasion
Caswell, P and Norman, J
Trends in Cell BiologyTrends in Cell Biology
(2 May 2008); doi: 10.1016/j.tcb.2008.03.004Real-time imaging reveals that noninvasive mammary epithelial acini can contain motile cells
Pearson, G. W. and Hunter, T.
The Journal of Cell BiologyThe Journal of Cell Biology 179 179
(31 December 2007); doi: 10.1083/jcb.200706099Notch and Integrin Affinity: A Sticky Situation
Karsan, A.
Science SignalingScience Signaling 1 1
(8 January 2008); doi: 10.1126/stke.12pe2Angiogenesis selectively requires the p110
isoform of PI3K to control endothelial cell migrationGraupera, Mariona et al.
NatureNature
(30 April 2008); doi: 10.1038/nature06892Nudel Binds Cdc42GAP to Modulate Cdc42 Activity at the Leading Edge of Migrating Cells
Shen, Y et al.
Developmental CellDevelopmental Cell 14 14
(11 March 2008); doi: 10.1016/j.devcel.2008.01.001Gating of Sema3E/PlexinD1 Signaling by Neuropilin-1 Switches Axonal Repulsion to Attraction during Brain Development
Chauvet, S et al.
NeuronNeuron 56 56
(6 December 2007); doi: 10.1016/j.neuron.2007.10.019Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1
Fukuhara, Shigetomo et al.
Nature Cell BiologyNature Cell Biology
(20 April 2008); doi: 10.1038/ncb1714Yes and PI3K Bind CD95 to Signal Invasion of Glioblastoma
Kleber, S
Cancer CellCancer Cell 13 13
(11 March 2008); doi: 10.1016/j.ccr.2008.02.003Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts
Saharinen, Pipsa et al.
Nature Cell BiologyNature Cell Biology
(20 April 2008); doi: 10.1038/ncb1715Disruption of PDGFR -initiated PI3K activation and migration of somite derivatives leads to spina bifida
Pickett, E. A., Olsen, G. S. and Tallquist, M. D.
DevelopmentDevelopment 135 135
(2 January 2008); doi: 10.1242/dev.013763HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion
Du, R
Cancer CellCancer Cell 13 13
(11 March 2008); doi: 10.1016/j.ccr.2008.01.034Integrins in angiogenesis and lymphangiogenesis
Avraamides, Christie J., Garmy-susini, Barbara and Varner, Judith A.
Nature Reviews CancerNature Reviews Cancer
(22 May 2008); doi: 10.1038/nrc2353Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis
Caunt, M et al.
Cancer CellCancer Cell 13 13
(8 April 2008); doi: 10.1016/j.ccr.2008.01.029PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE
Pinner, Sophie and Sahai, Erik
Nature Cell BiologyNature Cell Biology 10 10 127 - 137
(20 January 2008); doi: 10.1038/ncb1675Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor expression
Finzsch, M., Stolt, C. C., Lommes, P. and Wegner, M.
DevelopmentDevelopment 135 135
(15 February 2008); doi: 10.1242/dev.010454The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility
Pandithage, R. et al.
The Journal of Cell BiologyThe Journal of Cell Biology 180 180
(10 March 2008); doi: 10.1083/jcb.200707126Regulation of Cell Adhesion and Collective Cell Migration by Hindsight and Its Human Homolog RREB1
Melani, M, Simpson, K, Brugge, J and Montell, D
Current BiologyCurrent Biology 18 18
(8 April 2008); doi: 10.1016/j.cub.2008.03.024Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion
Cortesio, C. L. et al.
The Journal of Cell BiologyThe Journal of Cell Biology 180 180
(10 March 2008); doi: 10.1083/jcb.200708048JNK Signaling Controls Border Cell Cluster Integrity and Collective Cell Migration
Llense, F and Martinblanco, E
Current BiologyCurrent Biology 18 18
(8 April 2008); doi: 10.1016/j.cub.2008.03.029Cooperation of polarized cell intercalations drives convergence and extension of presomitic mesoderm during zebrafish gastrulation
Yin, C. et al.
The Journal of Cell BiologyThe Journal of Cell Biology 180 180
(7 January 2008); doi: 10.1083/jcb.200704150Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2
Abou-kheir, W., Isaac, B., Yamaguchi, H. and Cox, D.
Journal of Cell ScienceJournal of Cell Science 121 121
(15 January 2008); doi: 10.1242/jcs.010272Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascades
Nath, A. K. et al.
The Journal of Cell BiologyThe Journal of Cell Biology 181 181
(21 April 2008); doi: 10.1083/jcb.200708197Regulation of In Situ to Invasive Breast Carcinoma Transition
Hu, M et al.
Cancer CellCancer Cell 13 13
(6 May 2008); doi: 10.1016/j.ccr.2008.03.007Caspase-8 Interacts with the p85 Subunit of Phosphatidylinositol 3-Kinase to Regulate Cell Adhesion and Motility
Senft, J., Helfer, B. and Frisch, S. M.
Cancer ResearchCancer Research 67 67
(15 December 2007); doi: 10.1158/0008-5472.CAN-07-5755Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence
Schleicher, M. et al.
The Journal of Cell BiologyThe Journal of Cell Biology 180 180
(7 January 2008); doi: 10.1083/jcb.200706072Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism
Fang, W. B. et al.
Journal of Cell ScienceJournal of Cell Science 121 121
(15 January 2008); doi: 10.1242/jcs.017145WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells
Sarmiento, C. et al.
The Journal of Cell BiologyThe Journal of Cell Biology 180 180
(24 March 2008); doi: 10.1083/jcb.200708123ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration
Yamauchi, J., Miyamoto, Y., Chan, J. R. and Tanoue, A.
The Journal of Cell BiologyThe Journal of Cell Biology 181 181
(21 April 2008); doi: 10.1083/jcb.200709033PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility
Lim, Y. et al.
The Journal of Cell BiologyThe Journal of Cell Biology 180 180
(7 January 2008); doi: 10.1083/jcb.200708194A hypoxic twist in metastasis
Peinado, Héctor and Cano, Amparo
Nature Cell BiologyNature Cell Biology 10 10 253 - 254
doi: 10.1038/ncb0308-253Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway
Zeidan, Y. H., Jenkins, R. W. and Hannun, Y. A.
The Journal of Cell BiologyThe Journal of Cell Biology 181 181
(21 April 2008); doi: 10.1083/jcb.200705060Quantification of integrin receptor agonism by fluorescence lifetime imaging
Parsons, M. et al.
Journal of Cell ScienceJournal of Cell Science 121 121
(15 January 2008); doi: 10.1242/jcs.018440Cell–Matrix Adhesion: The Wech Connection
Delon, I and Brown, N
Current BiologyCurrent Biology 18 18
(6 May 2008); doi: 10.1016/j.cub.2008.03.047An Integrin Phosphorylation Switch: THE EFFECT OF 3 INTEGRIN TAIL PHOSPHORYLATION ON DOK1 AND TALIN BINDING
Oxley, C. L. et al.
Journal of Biological ChemistryJournal of Biological Chemistry 283 283
(11 December 2007); doi: 10.1074/jbc.M709435200Plexin-A2 and its ligand, Sema6A, control nucleus-centrosome coupling in migrating granule cells
Renaud, Julie et al.
Nature NeuroscienceNature Neuroscience 11 11 440 - 449
(9 March 2008); doi: 10.1038/nn2064Kindlin-2 (Mig-2): a co-activator of 3 integrins
Ma, Y.-Q., Qin, J., Wu, C. and Plow, E. F.
The Journal of Cell BiologyThe Journal of Cell Biology 181 181
(28 April 2008); doi: 10.1083/jcb.200710196Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells
Jeon, T. J. et al.
The Journal of Cell BiologyThe Journal of Cell Biology 179 179
(3 December 2007); doi: 10.1083/jcb.200705068Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors
Pi, X. et al.
The Journal of Cell BiologyThe Journal of Cell Biology 179 179
(31 December 2007); doi: 10.1083/jcb.200704010Disruption of c-Jun Reduces Cellular Migration and Invasion through Inhibition of c-Src and Hyperactivation of ROCK II Kinase
Jiao, X. et al.
Molecular Biology of the CellMolecular Biology of the Cell 19 19
(1 April 2008); doi: 10.1091/mbc.E07-08-0753iPLA2 : front and center in human monocyte chemotaxis to MCP-1
Mishra, R. S., Carnevale, K. A. and Cathcart, M. K.
Journal of Experimental MedicineJournal of Experimental Medicine 205 205
(11 February 2008); doi: 10.1084/jem.20071243Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling
Kakinuma, N. et al.
The Journal of Cell BiologyThe Journal of Cell Biology 181 181
(28 April 2008); doi: 10.1083/jcb.200707022Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement
Lacalle, R. A. et al.
The Journal of Cell BiologyThe Journal of Cell Biology 179 179
(31 December 2007); doi: 10.1083/jcb.200705044EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells
Van rheenen, J. et al.
The Journal of Cell BiologyThe Journal of Cell Biology 179 179
(17 December 2007); doi: 10.1083/jcb.200706206Multiple regulatory inputs converge on cortactin to control invadopodia biogenesis and extracellular matrix degradation
Ayala, I. et al.
Journal of Cell ScienceJournal of Cell Science 121 121
(15 January 2008); doi: 10.1242/jcs.008037A spatially restricted increase in receptor mobility is involved in directional sensing during Dictyostelium discoideum chemotaxis
De keijzer, S. et al.
Journal of Cell ScienceJournal of Cell Science 121 121
(22 April 2008); doi: 10.1242/jcs.030692SmgGDS Regulates Cell Proliferation, Migration, and NF- B Transcriptional Activity in Non-small Cell Lung Carcinoma
Tew, G. W. et al.
Journal of Biological ChemistryJournal of Biological Chemistry 283 283
(8 November 2007); doi: 10.1074/jbc.M707526200Four key signaling pathways mediating chemotaxis in Dictyostelium discoideum
Veltman, D. M., Keizer-gunnik, I. and Van haastert, P. J.M.
The Journal of Cell BiologyThe Journal of Cell Biology 180 180
(11 February 2008); doi: 10.1083/jcb.200709180Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA
Matthews, H. K. et al.
DevelopmentDevelopment 135 135
(9 April 2008); doi: 10.1242/dev.017350Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase
Owen, K. A. et al.
The Journal of Cell BiologyThe Journal of Cell Biology 179 179
(17 December 2007); doi: 10.1083/jcb.200708093cAMP Inhibits Cell Migration by Interfering with Rac-induced Lamellipodium Formation
Chen, L., Zhang, J. J. and Huang, X.-Y.
Journal of Biological ChemistryJournal of Biological Chemistry 283 283
(27 March 2008); doi: 10.1074/jbc.M800555200Inflammatory levels of nitric oxide inhibit airway epithelial cell migration by inhibition of the kinase ERK1/2 and activation of hypoxia-inducible factor-1alpha
Bove, P. F. et al.
Journal of Biological ChemistryJournal of Biological Chemistry
(18 April 2008); doi: 10.1074/jbc.M709914200Effector Proteins Exert an Important Influence on the Signaling-active State of the Small GTPase Cdc42
Phillips, M. J. et al.
Journal of Biological ChemistryJournal of Biological Chemistry 283 283
(27 March 2008); doi: 10.1074/jbc.M706271200Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of alpha 2beta 1 integrin activity
Fiedler, L. R. et al.
Journal of Biological ChemistryJournal of Biological Chemistry
(15 April 2008); doi: 10.1074/jbc.M710025200Fibroblast migration is mediated by CD44-dependent TGF activation
Acharya, P. S. et al.
Journal of Cell ScienceJournal of Cell Science 121 121
(8 April 2008); doi: 10.1242/jcs.021683Protein-tyrosine Phosphatase PTPD1 Regulates Focal Adhesion Kinase Autophosphorylation and Cell Migration
Carlucci, A. et al.
Journal of Biological ChemistryJournal of Biological Chemistry 283 283
(19 February 2008); doi: 10.1074/jbc.M707248200PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac
Lozano, E. et al.
Journal of Cell ScienceJournal of Cell Science 121 121
(11 March 2008); doi: 10.1242/jcs.016121Rho-Kinase Phosphorylates PAR-3 and Disrupts PAR Complex Formation
Nakayama, M et al.
Developmental CellDevelopmental Cell 14 14
(12 February 2008); doi: 10.1016/j.devcel.2007.11.021Notch signaling mediates hypoxia-induced tumor cell migration and invasion
Sahlgren, C. et al.
Proceedings of the National Academy of SciencesProceedings of the National Academy of Sciences 105 105
(29 April 2008); doi: 10.1073/pnas.0802047105The PAR-6 Polarity Protein Regulates Dendritic Spine Morphogenesis through p190 RhoGAP and the Rho GTPase
Zhang, H and Macara, I
Developmental CellDevelopmental Cell 14 14
(12 February 2008); doi: 10.1016/j.devcel.2007.11.020Cadherin switching
Wheelock, M. J. et al.
Journal of Cell ScienceJournal of Cell Science 121 121
(26 February 2008); doi: 10.1242/jcs.000455On the Rho'd: The regulation of membrane protrusions by Rho-GTPases
Ladwein, M and Rottner, K
FEBS LettersFEBS Letters
(28 April 2008); doi: 10.1016/j.febslet.2008.04.033Dialogue between RhoA/ROCK and Members of the Par Complex in Cell Polarity
Sordella, R and Vanaelst, L
Developmental CellDevelopmental Cell 14 14
(12 February 2008); doi: 10.1016/j.devcel.2008.01.015FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts
Iwanicki, M. P. et al.
Journal of Cell ScienceJournal of Cell Science 121 121
(26 February 2008); doi: 10.1242/jcs.020941From the Cover: Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus
Kim, C. et al.
Proceedings of the National Academy of SciencesProceedings of the National Academy of Sciences 105 105
(22 April 2008); doi: 10.1073/pnas.0800105105Migratory neighbors and distant invaders: tumor-associated niche cells
Genes & Dev. 22, 559-574 (2008)
Kruppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase
Yang, Y. et al.
Journal of Biological ChemistryJournal of Biological Chemistry
(1 May 2008); doi: 10.1074/jbc.M801384200Regulation of Cancer Cell Survival, Migration, and Invasion by Twist: AKT2 Comes to Interplay
Cheng, G. Z., Zhang, W. and Wang, L.-H.
Cancer ResearchCancer Research 68 68
(15 February 2008); doi: 10.1158/0008-5472.CAN-07-5067Proliferation vs migration in PDGF signaling: The key role of endocytosis
De donatis, A. et al.
Journal of Biological ChemistryJournal of Biological Chemistry
(22 May 2008); doi: 10.1074/jbc.M709428200The 9 1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel
Dehart, G. W. et al.
Proceedings of the National Academy of SciencesProceedings of the National Academy of Sciences 105 105
(20 May 2008); doi: 10.1073/pnas.0708044105Extracellular matrix protein b-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation
Genes & Dev. 22, 308-321 (2008)
Fibronectin fibrillogenesis regulates three-dimensional neovessel formation
Genes & Dev. 22, 1231-1243 (2008)
Kindlin-2 controls bidirectional signaling of integrins
Genes & Dev. 22, 1325-1330 (2008)