2007 Signalling

• p120-Catenin and p190RhoGAP Regulate Cell-Cell Adhesion by Coordinating Antagonism between Rac and Rho

  Wildenberg, G et al.
  Cell 127
  (1 December 2006); doi: 10.1016/j.cell.2006.09.046

  Abstract

• Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix

  Bass, M. D. et al.
  The Journal of Cell Biology 177
  (30 April 2007); doi: 10.1083/jcb.200610076

  Abstract

• Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis

  Van haastert, P. J.M., Keizer-gunnink, I. and Kortholt, A.
  The Journal of Cell Biology 177
  (21 June 2007); doi: 10.1083/jcb.200701134

  Abstract

• NHERF Links the N-Cadherin/Catenin Complex to the Platelet-derived Growth Factor Receptor to Modulate the Actin Cytoskeleton and Regulate Cell Motility

  Theisen, C. S., Wahl, J. K., Johnson, K. R. and Wheelock, M. J.
  Molecular Biology of the Cell 18
  (17 January 2007); doi: 10.1091/mbc.E06-10-0960

  Abstract

• Chemotaxis in the Absence of PIP3 Gradients

  Hoeller, O and Kay, R
  Current Biology 17
  (1 May 2007); doi: 10.1016/j.cub.2007.04.004

  Abstract

• Quantitative Morphological Signatures Define Local Signaling Networks Regulating Cell Morphology

  Bakal, C., Aach, J., Church, G. and Perrimon, N.
  Science 316
  (22 June 2007); doi: 10.1126/science.1140324

  Abstract

• Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion

  Yamazaki, D., Oikawa, T. and Takenawa, T.
  Journal of Cell Science 120
  (12 December 2006); doi: 10.1242/jcs.03311

  Abstract

• Hardwiring the Brain: Endocannabinoids Shape Neuronal Connectivity

  Berghuis, P. et al.
  Science 316
  (25 May 2007); doi: 10.1126/science.1137406

  Abstract

• Stopping Ras in Its Tracks

  Der, C and Vandyke, T
  Cell 129
  (1 June 2007); doi: 10.1016/j.cell.2007.05.031

  Abstract

• Des- -carboxyl Prothrombin-promoted Vascular Endothelial Cell Proliferation and Migration

  Fujikawa, T. et al.
  Journal of Biological Chemistry 282
  (19 January 2007); doi: 10.1074/jbc.M609358200

  Abstract

• Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice

  Gupta, S et al.
  Cell 129
  (1 June 2007); doi: 10.1016/j.cell.2007.03.051

  Abstract

• NF-B in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF

  Park, Bae Keun et al.
  Nature Medicine 13 62 - 69
  (10 December 2006); doi: 10.1038/nm1519

  Abstract

• Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SET

  
  doi: 10.1038/sj.emboj.7601518

  Abstract

• CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node.

  J Immunol.
  

  Abstract

• RhoA Mediates Cyclooxygenase-2 Signaling to Disrupt the Formation of Adherens Junctions and Increase Cell Motility

  Chang, Y.-W. E., Marlin, J. W., Chance, T. W. and Jakobi, R.
  Cancer Research 66
  (15 December 2006); doi: 10.1158/0008-5472.CAN-06-1818

  Abstract

• Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions

  Andrew, Natalie and Insall, Robert H
  Nature Cell Biology 9 193 - 200
  (14 January 2007); doi: 10.1038/ncb1536

  Abstract

• Calmodulin-like Protein Increases Filopodia-dependent Cell Motility via Up-regulation of Myosin-10

  Bennett, R. D., Mauer, A. S. and Strehler, E. E.
  Journal of Biological Chemistry 282
  (5 December 2006); doi: 10.1074/jbc.M607174200

  Abstract

• The Transmembrane Protein Kon-tiki Couples to Dgrip to Mediate Myotube Targeting in Drosophila

  Schnorrer, F, Kalchhauser, I and Dickson, B
  Developmental Cell 12
  (8 May 2007); doi: 10.1016/j.devcel.2007.02.017

  Abstract

• Syndecan-2 induces filopodia and dendritic spine formation via the neurofibromin-PKA-Ena/VASP pathway

  Lin, Y.-L., Lei, Y.-T., Hong, C.-J. and Hsueh, Y.-P.
  The Journal of Cell Biology 177
  (21 June 2007); doi: 10.1083/jcb.200608121

  Abstract

• Somatic Excision Demonstrates that c-Jun Induces Cellular Migration and Invasion through Induction of Stem Cell Factor

  Katiyar, S. et al.
  Molecular and Cellular Biology 27
  (4 December 2006); doi: 10.1128/MCB.01061-06

  Abstract

• Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling

  Keizer-gunnink, I., Kortholt, A. and Van haastert, P. J.M.
  The Journal of Cell Biology 177
  (21 May 2007); doi: 10.1083/jcb.200611046

  Abstract

• uPAR-induced cell adhesion and migration: vitronectin provides the key

  Madsen, C. D. et al.
  The Journal of Cell Biology 177
  (21 June 2007); doi: 10.1083/jcb.200612058

  Abstract

• A Ras Inhibitor Tilts the Balance between Rac and Rho and Blocks Phosphatidylinositol 3-Kinase-Dependent Glioblastoma Cell Migration

  Goldberg, L. and Kloog, Y.
  Cancer Research 66
  (15 December 2006); doi: 10.1158/0008-5472.CAN-06-1878

  Abstract

• Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases

  Grande-garcia, A. et al.
  The Journal of Cell Biology 177
  (21 May 2007); doi: 10.1083/jcb.200701006

  Abstract

• PI(3)K has an important context-dependent role in neutrophil chemokinesis

  Ferguson, G. John et al.
  Nature Cell Biology 9 86 - 91
  (17 December 2006); doi: 10.1038/ncb1517

  Abstract

• Sp1 Is Required for Transforming Growth Factor- -Induced Mesenchymal Transition and Migration in Pancreatic Cancer Cells

  Jungert, K. et al.
  Cancer Research 67
  (15 February 2007); doi: 10.1158/0008-5472.CAN-06-1670

  Abstract

• Caspase-11 regulates cell migration by promoting Aip1–Cofilin-mediated actin depolymerization

  Li, Juying et al.
  Nature Cell Biology 9 276 - 286
  (11 February 2007); doi: 10.1038/ncb1541

  Abstract

• Deficiency in the LIM-only protein Fhl2 impairs skin wound healing

  Wixler, V. et al.
  The Journal of Cell Biology 177
  (2 April 2007); doi: 10.1083/jcb.200606043

  Abstract

• Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex

  Ohshima, T. et al.
  Development 134
  (16 May 2007); doi: 10.1242/dev.02854

  Abstract

• The Chemokine SDF1a Coordinates Tissue Migration through the Spatially Restricted Activation of Cxcr7 and Cxcr4b

  Valentin, G, Haas, P and Gilmour, D
  Current Biology 17
  (19 June 2007); doi: 10.1016/j.cub.2007.05.020

  Abstract

• ATP Release Guides Neutrophil Chemotaxis via P2Y2 and A3 Receptors

  Chen, Y. et al.
  Science 314
  (15 December 2006); doi: 10.1126/science.1132559

  Abstract

• Yeast Mitochondrial Division and Distribution Require the Cortical Num1 Protein

  Cerveny, K, Studer, S, Jensen, R and Sesaki, H
  Developmental Cell 12
  (10 August 0009); doi: 10.1016/j.devcel.2007.01.017

  Abstract

• The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration

  Chuang, Y.-y. et al.
  Journal of Cell Science 120
  (1 June 2007); doi: 10.1242/jcs.03456

  Abstract

• S-adenosylhomocysteine hydrolase is localized at the front of chemotaxing cells, suggesting a role for transmethylation during migration

  Shu, S. et al.
  Proceedings of the National Academy of Sciences 103
  (26 December 2006); doi: 10.1073/pnas.0609385103

  Abstract

• Regulation of Arf6 and ACAP1 Signaling by the PTB-Domain-Containing Adaptor Protein GULP

  Ma, Z et al.
  Current Biology 17
  (17 April 2007); doi: 10.1016/j.cub.2007.03.014

  Abstract

• Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis

  Jovceva, E. et al.
  Journal of Cell Science 120
  (1 June 2007); doi: 10.1242/jcs.004366

  Abstract

• CD99 Is a Key Mediator of the Transendothelial Migration of Neutrophils

  J Immunol.
  

  Abstract

• Receptor-Mediated and Intrinsic Polarization and Their Interaction in Chemotaxing Cells

  Krishnan, J. and Iglesias, P. A.
  Biophysical Journal 92
  (10 November 2006); doi: 10.1529/biophysj.106.087353

  Abstract

• Phosphorylated ERM Is Responsible for Increased T Cell Polarization, Adhesion, and Migration in Patients with Systemic Lupus Erythematosus

  J Immunol.
  

  Abstract

• Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility

  Sahai, E., Garcia-medina, R., Pouyssegur, J. and Vial, E.
  The Journal of Cell Biology 176
  (2 January 2007); doi: 10.1083/jcb.200605135

  Abstract

• Two distinct modes of myosin assembly and dynamics during epithelial wound closure

  Tamada, M., Perez, T. D., Nelson, W. J. and Sheetz, M. P.
  The Journal of Cell Biology 176
  (2 January 2007); doi: 10.1083/jcb.200609116

  Abstract

• Dia-Interacting Protein Modulates Formin-Mediated Actin Assembly at the Cell Cortex

  Eisenmann, K et al.
  Current Biology 17
  (3 April 2007); doi: 10.1016/j.cub.2007.03.024

  Abstract

• Migration of CD4 T Cells and Dendritic Cells toward Sphingosine 1-Phosphate (S1P) Is Mediated by Different Receptor Subtypes: S1P Regulates the Functions of Murine Mature Dendritic Cells via S1P Receptor Type 3.

  J Immunol.
  

  Abstract

• IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly

  Bensenor, L. B. et al.
  Journal of Cell Science 120
  (15 February 2007); doi: 10.1242/jcs.03376

  Abstract

• RhoB plays an essential role in CXCR2 sorting decisions

  Neel, N. F., Lapierre, L. A., Goldenring, J. R. and Richmond, A.
  Journal of Cell Science 120
  (3 April 2007); doi: 10.1242/jcs.03437

  Abstract

• The Bmp Gradient of the Zebrafish Gastrula Guides Migrating Lateral Cells by Regulating Cell-Cell Adhesion

  Curr. Biol.
  

  Abstract

• Metastatic Potential of 21T Human Breast Cancer Cells Depends on Akt/Protein Kinase B Activation

  Qiao, M., Iglehart, J. D. and Pardee, A. B.
  Cancer Research 67
  (1 June 2007); doi: 10.1158/0008-5472.CAN-07-0877

  Abstract

• Rho Kinase Differentially Regulates Phosphorylation of Nonmuscle Myosin II Isoforms A and B during Cell Rounding and Migration

  Sandquist, J. C. et al.
  Journal of Biological Chemistry 281
  (14 September 2006); doi: 10.1074/jbc.M605343200

  Abstract

• Vertebrate Gastrulation: The BMP Sticker Shock

  Wallingford, J and Harland, R
  Current Biology 17
  (20 March 2007); doi: 10.1016/j.cub.2007.02.010

  Abstract

• Ena/VASP proteins mediate repulsion from ephrin ligands

  Evans, I. R., Renne, T., Gertler, F. B. and Nobes, C. D.
  Journal of Cell Science 120
  (15 January 2007); doi: 10.1242/jcs.03333

  Abstract

• Akt1 governs breast cancer progression in vivo

  Ju, X. et al.
  Proceedings of the National Academy of Sciences 104
  (25 April 2007); doi: 10.1073/pnas.0605874104

  Abstract

• Anthrax lethal toxin paralyzes actin-based motility by blocking Hsp27 phosphorylation

  
  doi: 10.1038/sj.emboj.7601687

  Abstract

• Autologous Chemotaxis as a Mechanism of Tumor Cell Homing to Lymphatics via Interstitial Flow and Autocrine CCR7 Signaling

  Shields, J et al.
  Cancer Cell 11
  (12 June 2007); doi: 10.1016/j.ccr.2007.04.020

  Abstract

• Mutations in α-Tubulin Cause Abnormal Neuronal Migration in Mice and Lissencephaly in Humans

  Keays, D et al.
  Cell 128
  (12 January 2007); doi: 10.1016/j.cell.2006.12.017

  Abstract

• Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility

  Seifert, Jessica R. K. and Mlodzik, Marek
  Nature Reviews Genetics 8 126 - 138
  doi: 10.1038/nrg2042

  Abstract

• Neuronal polarity: from extracellular signals to intracellular mechanisms

  Arimura, Nariko and Kaibuchi, Kozo
  Nature Reviews Neuroscience 8 194 - 205
  doi: 10.1038/nrn2056

  Abstract

• Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs

  Kae, Helmut et al.
  EMBO reports 8
  (23 April 0011); doi: 10.1038/sj.embor.7400936

  Abstract

• Extracellular heat shock protein-90α: linking hypoxia to skin cell motility and wound healing

  Li, Wei et al.
  The EMBO Journal 26
  (12 October 0008); doi: 10.1038/sj.emboj.7601579

  Abstract

• Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1

  Tscharntke, M. et al.
  Journal of Cell Science 120
  (27 March 2007); doi: 10.1242/jcs.03426

  Abstract

• Angiopoietin-2 Stimulates Breast Cancer Metastasis through the  5 1 Integrin-Mediated Pathway

  Imanishi, Y. et al.
  Cancer Research 67
  (24 April 2007); doi: 10.1158/0008-5472.CAN-06-4100

  Abstract

• Receptor for advanced glycation endproducts mediates neutrophil migration across intestinal epithelium

  J Immunol.
  

  Abstract

• Dlx Transcription Factors Promote Migration through Repression of Axon and Dendrite Growth

  Cobos, I, Borello, U and Rubenstein, J
  Neuron 54
  (21 June 2007); doi: 10.1016/j.neuron.2007.05.024

  Abstract

• MEKK4 Signaling Regulates Filamin Expression and Neuronal Migration

  Sarkisian, M et al.
  Neuron 52
  (7 December 2006); doi: 10.1016/j.neuron.2006.10.024

  Abstract

• Phosphorylation of adducin by protein kinase C  promotes cell motility

  Chen, C.-L., Hsieh, Y.-T. and Chen, H.-C.
  Journal of Cell Science 120
  (1 April 2007); doi: 10.1242/jcs.03408

  Abstract

• The Tyrosine Phosphatase Shp2 Interacts with NPM-ALK and Regulates Anaplastic Lymphoma Cell Growth and Migration

  Voena, C. et al.
  Cancer Research 67
  (24 April 2007); doi: 10.1158/0008-5472.CAN-06-4350

  Abstract

• J Immunol.
  

  Abstract

• Cortical Interneurons Refuse to Follow the PAK

  Guillemot, F
  Neuron 54
  (21 June 2007); doi: 10.1016/j.neuron.2007.06.009

  Abstract

• Control of cell polarity and motility by the PtdIns(3,4,5)P₃ phosphatase SHIP1

  Nishio, Miki et al.
  Nature Cell Biology 9 36 - 44
  (17 December 2006); doi: 10.1038/ncb1515

  Abstract

• The ADMA/DDAH pathway is a critical regulator of endothelial cell motility

  Wojciak-stothard, B. et al.
  Journal of Cell Science 120
  (27 February 2007); doi: 10.1242/jcs.002212

  Abstract

• MEK1 and Protein Phosphatase 4 Coordinate Dictyostelium Development and Chemotaxis

  Mendoza, M. C., Booth, E. O., Shaulsky, G. and Firtel, R. A.
  Molecular and Cellular Biology 27
  (12 March 2007); doi: 10.1128/MCB.02194-06

  Abstract

• Leading-edge research: PtdIns(3,4,5)P₃ and directed migration

  Franca-koh, Jonathan, Kamimura, Yoichiro and Devreotes, Peter N.
  Nature Cell Biology 9 15 - 17
  doi: 10.1038/ncb0107-15

  Abstract

• PtdIns(3,4,5)P3-Dependent and -Independent Roles for PTEN in the Control of Cell Migration

  Leslie, N, Yang, X, Downes, C and Weijer, C
  Current Biology 17
  (23 January 2007); doi: 10.1016/j.cub.2006.12.026

  Abstract

• Rho activation at a glance

  Buchsbaum, R. J.
  Journal of Cell Science 120
  (1 April 2007); doi: 10.1242/jcs.03428

  Abstract

• LIM Kinase and Slingshot Are Critical for Neurite Extension

  Endo, M., Ohashi, K. and Mizuno, K.
  Journal of Biological Chemistry 282
  (16 March 2007); doi: 10.1074/jbc.M610873200

  Abstract

• p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration

  
  doi: 10.1038/sj.emboj.7601457

  Abstract

• Endogenous ARF6 Interacts with Rac1 upon Angiotensin II Stimulation to Regulate Membrane Ruffling and Cell Migration

  Cotton, M. et al.
  Molecular Biology of the Cell 18
  (15 November 2006); doi: 10.1091/mbc.E06-06-0567

  Abstract

• Gravin regulates mesodermal cell behavior changes required for axis elongation during zebrafish gastrulation

  Genes & Dev. 21, 1559-1571 (2007)
  

  Abstract

• Gravin regulates mesodermal cell behavior changes required for axis elongation during zebrafish gastrulation

  Genes & Dev. 21, 1559-1571 (2007)
  

  Abstract

• Profiling signaling polarity in chemotactic cells CMC

  Wang, Y. et al.
  Proceedings of the National Academy of Sciences 104
  (15 May 2007); doi: 10.1073/pnas.0701103104

  Abstract

• Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion

  Genes & Dev. 21, 1478-1483 (2007)
  

  Abstract

• Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion

  Genes & Dev. 21, 1478-1483 (2007)
  

  Abstract

• A silent chemokine receptor regulates steady-state leukocyte homing in vivo

  Heinzel, K., Benz, C. and Bleul, C. C.
  Proceedings of the National Academy of Sciences 104
  (15 May 2007); doi: 10.1073/pnas.0608274104

  Abstract

• IL-10 regulates movement of intestinally derived CD4+ T cells to the liver

  J. Immunol. 178, 7974-7983 (2007)
  

  Abstract

• IL-10 regulates movement of intestinally derived CD4+ T cells to the liver

  J. Immunol. 178, 7974-7983 (2007)
  

  Abstract

• ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin

  Andrade, N. et al.
  Proceedings of the National Academy of Sciences 104
  (15 May 2007); doi: 10.1073/pnas.0611391104

  Abstract

• Definition of Germinal-Center B Cell Migration In Vivo Reveals Predominant Intrazonal Circulation Patterns

  Immunity 26, 655-667 (2007)
  

  Abstract

• Neutrophil Transmigration under Shear Flow Conditions In Vitro Is Junctional Adhesion Molecule-C Independent

  J Immunol.
  

  Abstract

• Coronin Function Is Required for Chemotaxis and Phagocytosis in Human Neutrophils

  J Immunol.
  

  Abstract