Subject archive
2005 Signalling
A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling
Côté, Jean-François, Motoyama, Andrea B., Bush, Jason A. and Vuori, Kristiina
Nature Cell Biology 7 797 - 807
(17 July 2005); doi: 10.1038/ncb1280Regulatory mechanisms required for DE-cadherin function in cell migration and other types of adhesion
Pacquelet, A.
The Journal of Cell Biology 170
(29 August 2005); doi: 10.1083/jcb.200506131Spatial regulation of
-actin translation by Src-dependent phosphorylation of ZBP1Hüttelmaier, Stefan et al.
Nature 438 512 - 515
doi: 10.1038/nature04115Rac and cell migration: CDM proteins integrate signals
Bourne, Henry R.
Nature Cell Biology 7 777 - 778
doi: 10.1038/ncb0805-777Prohibitin is required for Ras-induced Raf–MEK–ERK activation and epithelial cell migration
Rajalingam, Krishnaraj et al.
Nature Cell Biology 7 837 - 843
(24 July 2005); doi: 10.1038/ncb1283Regulation of cadherin-mediated adhesion in morphogenesis
Gumbiner, Barry M.
Nature Reviews Molecular Cell Biology 6 622 - 634
(15 July 2005); doi: 10.1038/nrm1699Integrin 4 1 Promotes Focal Adhesion Kinase-Independent Cell Motility via 4 Cytoplasmic Domain-Specific Activation of c-Src
Hsia, D. A.
Molecular and Cellular Biology 25
(1 November 2005); doi: 10.1128/MCB.25.21.9700-9712.2005Monocyte Adhesion to Xenogeneic Endothelium during Laminar Flow Is Dependent on a-Gal-Mediated Monocyte Activation
The Journal of Immunology
v 3-integrin-dependent activation of focal adhesion kinase mediates NF- B activation and motogenic activity by HIV-1 Tat in endothelial cells
Urbinati, C.
Journal of Cell Science 118
(1 September 2005); doi: 10.1242/jcs.02518Quantum Proteolytic Activation of Chemokine CCL15 by Neutrophil Granulocytes Modulates Mononuclear Cell Adhesiveness
The Journal of Immunology
Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase I b
Powner, D. J.
Journal of Cell Science 118
(1 July 2005); doi: 10.1242/jcs.02432Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells
Fleming, I.
Journal of Cell Science 118
(15 September 2005); doi: 10.1242/jcs.0254115(S)-Hydroxyeicosatetraenoic Acid Induces Angiogenesis via Activation of PI3K-Akt-mTOR-S6K1 Signaling
Cancer Research
The CD44 Receptor Interacts with P-Glycoprotein to Promote Cell Migration and Invasion in Cancer
Cancer Research
Hypersialylation of B1 Integrins, Observed in Colon Adenocarcinoma, May Contribute to Cancer Progression by Up-regulating Cell Motility
Cancer Research
CD44 Attenuates Metastatic Invasion during Breast Cancer Progression
Cancer Research
Inhibition of Adhesion, Invasion, and Metastasis by Antibodies Targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen)
Cancer Res.
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and -catenin translocation
Maretzky, T.
Proceedings of the National Academy of Sciences 102
(28 June 2005); doi: 10.1073/pnas.0500918102A Novel Role for Integrin-linked Kinase in Epithelial Sheet Morphogenesis
Vespa, A.
Molecular Biology of the Cell 16
(15 June 2005); doi: 10.1091/mbc.E05-02-0087Requirement for Focal Adhesion Kinase in the Early Phase of Mammary Adenocarcinoma Lung Metastasis Formation
Cancer Research
RalA and RalB: Antagonistic Relatives in Cancer Cell Migration
Cancer Research
Bordetella Type III Secretion Modulates Dendritic Cell Migration Resulting in Immunosuppression and Bacterial Persistence
J Immunol.
Src and FAK Kinases Cooperate to Phosphorylate Paxillin Kinase Linker, Stimulate Its Focal Adhesion Localization, and Regulate Cell Spreading and Protrusiveness
Brown, M. C.
Molecular Biology of the Cell 16
(15 June 2005); doi: 10.1091/mbc.E05-02-0131Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration
Nishita, M.
The Journal of Cell Biology 171
(24 October 2005); doi: 10.1083/jcb.200504029A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions
Cancer Research
c-Src-Mediated Phosphorylation of TRIP6 Regulates Its Function in Lysophosphatidic Acid-Induced Cell Migration
Mol. Cell. Biol.
Endogenous Osteonectin/SPARC/BM-40 Expression Inhibits MDA-MB-231 Breast Cancer Cell Metastasis
Cancer Research
Induction of Keratinocyte Migration via Transactivation of the Epidermal Growth Factor Receptor by the Antimicrobial Peptide LL-37
J Immunol.
Vascular Endothelial Cell Growth Factor Receptor 3-Mediated Activation of Lymphatic Endothelium Is Crucial for Tumor Cell Entry and Spread via Lymphatic Vessels
Cancer Research
Bcl-2 Promotes Invasion and Lung Metastasis by Inducing Matrix Metalloproteinase-2
Cancer Res.
Claudin-3 and Claudin-4 Expression in Ovarian Epithelial Cells Enhances Invasion and Is Associated with Increased Matrix Metalloproteinase-2 Activity
Cancer Research
Inhibition of Rho-Kinase Affects Astrocytoma Morphology, Motility, and Invasion through Activation of Rac1
Cancer Res.
Transendothelial Migration of Melanoma Cells Involves N-Cadherin-mediated Adhesion and Activation of the -Catenin Signaling Pathway
Qi, J.
Molecular Biology of the Cell 16
(15 June 2005); doi: 10.1091/mbc.E05-03-0186Phosphorylation of ACAP1 by Akt Regulates the Stimulation-Dependent Recycling of Integrin β1 to Control Cell Migration
Li, J et al.
Developmental Cell 9
(11 December 0005); doi: 10.1016/j.devcel.2005.09.012Lack of Telopeptides in Fibrillar Collagen I Promotes the Invasion of a Metastatic Breast Tumor Cell Line
Cancer Res.
The Journal of Immunology
Inhibition of Adhesion, Invasion, and Metastasis by Antibodies Targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen)
Cancer Res.
Essential role of CIB1 in regulating PAK1 activation and cell migration
Leisner, T. M.
The Journal of Cell Biology 170
(25 July 2005); doi: 10.1083/jcb.200502090Activation of the Canonical Wnt Pathway during Genital Keratinocyte Transformation: A Model for Cervical Cancer Progression
Cancer Res.
The Journal of Immunology
Inhibition of Rho-Kinase Affects Astrocytoma Morphology, Motility, and Invasion through Activation of Rac1
Cancer Res.
Taking the lid off focal adhesions
J. Cell Sci.
Reaching out for signals: filopodia sense EGF and respond by directed retrograde transport of activated receptors
Lidke, D. S.
The Journal of Cell Biology 170
(8 August 2005); doi: 10.1083/jcb.200503140Heat Shock Protein 60 Activates Cytokine-Associated Negative Regulator Suppressor of Cytokine Signaling 3 in T Cells: Effects on Signaling, Chemotaxis, and Inflammation
J Immunol.
Insulin-Like Growth Factor Binding Protein-5 Is a Target of Matrix Metalloproteinase-7: Implications for Epithelial-Mesenchymal Signaling
Cancer Research
Impact of Cutaneous IL-10 on Resident Epidermal Langerhans' Cells and the Development of Polarized Immune Responses
J Immunol.
A Network of PDZ-Containing Proteins Regulates T Cell Polarity and Morphology during Migration and Immunological Synapse Formation
Immunity
Rules of Recruitment for Th1 and Th2 Lymphocytes in Inflamed Liver: A Role for Alpha-4 Integrin and Vascular Adhesion Protein-1
Immunity
The sweet and sour of cancer: glycans as novel therapeutic targets
Fuster, Mark M. and Esko, Jeffrey D.
Nature Reviews Cancer 5 526 - 542
doi: 10.1038/nrc1649FAK-Mediated Src Phosphorylation of Endophilin A2 Inhibits Endocytosis of MT1-MMP and Promotes ECM Degradation
Wu, X, Gan, B, Yoo, Y and Guan, J
Developmental Cell 9
(10 October 0011); doi: 10.1016/j.devcel.2005.06.006The Journal of Immunology
Neutrophils Lacking Platelet-Endothelial Cell Adhesion Molecule-1 Exhibit Loss of Directionality and Motility in CXCR2-Mediated Chemotaxis
The Journal of Immunology
WAVE3-mediated Cell Migration and Lamellipodia Formation Are Regulated Downstream of Phosphatidylinositol 3-Kinase
Sossey-alaoui, K.
Journal of Biological Chemistry 280
(12 April 2005); doi: 10.1074/jbc.M500503200VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis
Matsumoto, Taro et al.
The EMBO Journal 24
(6 October 0006); doi: 10.1038/sj.emboj.7600709Regulators of Endocytosis Maintain Localized Receptor Tyrosine Kinase Signaling in Guided Migration
Jekely, G, Sung, H, Luque, C and Rorth, P
Developmental Cell 9
(10 October 0011); doi: 10.1016/j.devcel.2005.06.004A Non-Glycosaminoglycan-Binding Variant of CC Chemokine Ligand 7 (Monocyte Chemoattractant Protein-3) Antagonizes Chemokine-Mediated Inflammation
The Journal of Immunology
Syk Is Required for Monocyte/Macrophage Chemotaxis to CX3CL1 (Fractalkine)
The Journal of Immunology
Essential roles of G 12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements
Lin, F.
The Journal of Cell Biology 169
(6 June 2005); doi: 10.1083/jcb.200501104The Androgen Derivative 5a -Androstane-3
,17-Diol Inhibits Prostate Cancer Cell Migration Through Activation of the Estrogen Receptor SubtypeCancer Res.
Quantum Proteolytic Activation of Chemokine CCL15 by Neutrophil Granulocytes Modulates Mononuclear Cell Adhesiveness
The Journal of Immunology
Involvement of the RASSF1A Tumor Suppressor Gene in Controlling Cell Migration
Cancer Research
Heat Shock Protein 70 Surface-Positive Tumor Exosomes Stimulate Migratory and Cytolytic Activity of Natural Killer Cells
Cancer Res.
Characteristics of NK Cell Migration Early after Vaccinia Infection
The Journal of Immunology
Rules of Recruitment for Th1 and Th2 Lymphocytes in Inflamed Liver: A Role for Alpha-4 Integrin and Vascular Adhesion Protein-1
Immunity
Calcium mobilization stimulates Dictyostelium discoideum shear-flow-induced cell motility
Fache, S.
Journal of Cell Science 118
(1 August 2005); doi: 10.1242/jcs.02461Macrophages Promote the Invasion of Breast Carcinoma Cells via a Colony-Stimulating Factor-1/Epidermal Growth Factor Paracrine Loop
Cancer Res.
CC Chemokine Ligand 19 Secreted by Mature Dendritic Cells Increases Naive T Cell Scanning Behavior and Their Response to Rare Cognate Antigen
The Journal of Immunology
Sphingosine 1-Phosphate Receptors Regulate Chemokine-Driven Transendothelial Migration of Lymph Node but Not Splenic T Cells
The Journal of Immunology
Wounding activates p38 map kinase and activation transcription factor 3 in leading keratinocytes
Harper, E. G.
Journal of Cell Science 118
(1 August 2005); doi: 10.1242/jcs.02475Cutting Edge: Egress of Newly Generated Plasma Cells from Peripheral Lymph Nodes Depends on B2 Integrin
The Journal of Immunology
Carcinoma Invasion and Metastasis: A Role for Epithelial-Mesenchymal Transition?
Cancer Res.
Cutting Edge: Chemoattractant Receptor-Homologous Molecule Expressed on TH2 Cells Plays a Restricting Role on IL-5 Production and Eosinophil Recruitment
The Journal of Immunology
Sphingosine-1-Phosphate Mediates Migration of Mature Dendritic Cells
The Journal of Immunology
The Fallacy of Epithelial Mesenchymal Transition in Neoplasia
Cancer Res.
Neutrophils Lacking Platelet-Endothelial Cell Adhesion Molecule-1 Exhibit Loss of Directionality and Motility in CXCR2-Mediated Chemotaxis
The Journal of Immunology
Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration
Maffucci, T.
The Journal of Cell Biology 169
(6 June 2005); doi: 10.1083/jcb.200408005A Five-Amino-Acid Peptide Blocks Met- and Ron-Dependent Cell Migration
Cancer Res.
Syk Is Required for Monocyte/Macrophage Chemotaxis to CX3CL1 (Fractalkine)
The Journal of Immunology
The MEK1 Scaffolding Protein MP1 Regulates Cell Spreading by Integrating PAK1 and Rho Signals
Pullikuth, A.
Molecular and Cellular Biology 25
(15 June 2005); doi: 10.1128/MCB.25.12.5119-5133.2005A Mouse Model of Human Breast Cancer Metastasis to Human Bone
Ca2+ spikes in the flagellum control chemotactic behavior of sperm
doi: 10.1038/sj.emboj.7600744The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
Hamada, K.
Genes & Development 19
(1 September 2005); doi: 10.1101/gad.1308805Proteolytic Processing Converts the Repelling Signal Sema3E into an Inducer of Invasive Growth and Lung Metastasis
Cancer Res.
Intracellular Reactive Oxygen Species Activate Src Tyrosine Kinase during Cell Adhesion and Anchorage-Dependent Cell Growth
Giannoni, E.
Molecular and Cellular Biology 25
(1 August 2005); doi: 10.1128/MCB.25.15.6391-6403.2005Protein Kinase A Gating of a Pseudopodial-located RhoA/ROCK/p38/NHE1 Signal Module Regulates Invasion in Breast Cancer Cell Lines
Cardone, R. A.
Molecular Biology of the Cell 16
(13 April 2005); doi: 10.1091/mbc.E04-10-0945Chemokines: Integrators of Pain and Inflammation
White, Fletcher A., Bhangoo, Sonia K. and Miller, Richard J.
Nature Reviews Drug Discovery 4 834 - 844
doi: 10.1038/nrd1852Cdc42 Is Not Essential for Filopodium Formation, Directed Migration, Cell Polarization, and Mitosis in Fibroblastoid Cells
Czuchra, A.
Molecular Biology of the Cell 16
(19 July 2005); doi: 10.1091/mbc.E05-01-0061Impact of Cutaneous IL-10 on Resident Epidermal Langerhans' Cells and the Development of Polarized Immune Responses
J Immunol.
Netrin-1 inhibits leukocyte migration in vitro and in vivo
Ly, N. P.
Proceedings of the National Academy of Sciences 102
(11 October 2005); doi: 10.1073/pnas.0506233102Characterization of a Mouse Second Leukotriene B4 Receptor, mBLT2: BLT2-DEPENDENT ERK ACTIVATION AND CELL MIGRATION OF PRIMARY MOUSE KERATINOCYTES
Iizuka, Y.
Journal of Biological Chemistry 280
(25 April 2005); doi: 10.1074/jbc.M413257200Ca2+ Influx through L-type Ca2+ Channels Controls the Trailing Tail Contraction in Growth Factor-induced Fibroblast Cell Migration
Yang, S.
Journal of Biological Chemistry 280
(2 June 2005); doi: 10.1074/jbc.M501625200Cytoskeletal Interactions with the Outside World
Weaver, A
Developmental Cell 9
(10 December 0010); doi: 10.1016/j.devcel.2005.06.001Netrin-1 regulates invasion and migration of mouse mammary epithelial cells overexpressing Cripto-1 in vitro and in vivo
Strizzi, L.
Journal of Cell Science 118
(15 October 2005); doi: 10.1242/jcs.02574A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis
Rosu-myles, M.
Journal of Cell Science 118
(13 September 2005); doi: 10.1242/jcs.02555Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and -actinin are components of the nephrin multiprotein complex
Lehtonen, S.
Proceedings of the National Academy of Sciences 102
(12 July 2005); doi: 10.1073/pnas.0504166102Akt/PKB Regulates Actin Organization and Cell Motility via Girdin/APE
Enomoto, A et al.
Developmental Cell 9
(10 August 0012); doi: 10.1016/j.devcel.2005.08.001Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration
Yamauchi, J.
Proceedings of the National Academy of Sciences 102
(11 October 2005); doi: 10.1073/pnas.0507125102Dependence of Olfactory Bulb Neurogenesis on Prokineticin 2 Signaling
Ng, K. L.
Science 308
(24 June 2005); doi: 10.1126/science.1112103Biphasic Functions of the Kinase-defective Ephb6 Receptor in Cell Adhesion and Migration
Matsuoka, H.
Journal of Biological Chemistry 280
(7 June 2005); doi: 10.1074/jbc.M500010200Tumor Cell Pseudopodial Protrusions: LOCALIZED SIGNALING DOMAINS COORDINATING CYTOSKELETON REMODELING, CELL ADHESION, GLYCOLYSIS, RNA TRANSLOCATION, AND PROTEIN TRANSLATION
Jia, Z.
Journal of Biological Chemistry 280
(13 July 2005); doi: 10.1074/jbc.M501754200Integrin Regulation by RhoA in Thymocytes
J Immunol.
IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation
Mcloughlin, R. M.
Proceedings of the National Academy of Sciences 102
(22 June 2005); doi: 10.1073/pnas.0501794102G protein-coupled receptor signaling through Gq and JNK negatively regulates neural progenitor cell migration
Mizuno, N.
Proceedings of the National Academy of Sciences 102
(30 August 2005); doi: 10.1073/pnas.0506101102The CD44 Receptor Interacts with P-Glycoprotein to Promote Cell Migration and Invasion in Cancer
Cancer Research
CD44 Attenuates Metastatic Invasion during Breast Cancer Progression
Cancer Researc
RalA and RalB: Antagonistic Relatives in Cancer Cell Migration
Cancer Research
Cdc42 and Par6-PKC regulate the spatially localized association of Dlg1 and APC to control cell polarization
Etienne-manneville, S.
The Journal of Cell Biology 170
(12 September 2005); doi: 10.1083/jcb.20041217215(S)-Hydroxyeicosatetraenoic Acid Induces Angiogenesis via Activation of PI3K-Akt-mTOR-S6K1 Signaling
Cancer Research
A Rac switch regulates random versus directionally persistent cell migration
Pankov, R.
The Journal of Cell Biology 170
(29 August 2005); doi: 10.1083/jcb.200503152Insulin-Like Growth Factor Binding Protein-5 Is a Target of Matrix Metalloproteinase-7: Implications for Epithelial-Mesenchymal Signaling
Cancer Research
Role of Sphingosine Kinase 2 in Cell Migration toward Epidermal Growth Factor
Hait, N. C.
Journal of Biological Chemistry 280
(5 July 2005); doi: 10.1074/jbc.M502922200Endogenous Osteonectin/SPARC/BM-40 Expression Inhibits MDA-MB-231 Breast Cancer Cell Metastasis
Cancer Research
Phosphorylation of Coronin 1B by Protein Kinase C Regulates Interaction with Arp2/3 and Cell Motility
Cai, L.
Journal of Biological Chemistry 280
(16 July 2005); doi: 10.1074/jbc.M504146200Claudin-3 and Claudin-4 Expression in Ovarian Epithelial Cells Enhances Invasion and Is Associated with Increased Matrix Metalloproteinase-2 Activity
Cancer Research
A Network of PDZ-Containing Proteins Regulates T Cell Polarity and Morphology during Migration and Immunological Synapse Formation
Immunity
The Journal of Immunology
The Journal of Immunology
The Journal of Immunology
Quantum Proteolytic Activation of Chemokine CCL15 by Neutrophil Granulocytes Modulates Mononuclear Cell Adhesiveness
The Journal of Immunology
The Journal of Immunology
CC Chemokine Ligand 19 Secreted by Mature Dendritic Cells Increases Naive T Cell Scanning Behavior and Their Response to Rare Cognate Antigen
The Journal of Immunology
Cutting Edge: Chemoattractant Receptor-Homologous Molecule Expressed on TH2 Cells Plays a Restricting Role on IL-5 Production and Eosinophil Recruitment
The Journal of Immunology
Src-Dependent Tyrosine Phosphorylation at the Tips of Growth Cone Filopodia Promotes Extension
Robles, E.
Journal of Neuroscience 25
(17 August 2005); doi: 10.1523/JNEUROSCI.2680-05.2005