Subject archive
2011 Cancer
Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis
Goetz, Jacky G. et al.
Cell 146
(1 July 2011); doi: 10.1016/j.cell.2011.05.040Cancer Cells Exploit the Eph-Ephrin System to Promote Invasion and Metastasis: Tales of Unwitting Partners
Wang, B.
Science Signaling 4
(31 May 2011); doi: 10.1126/scisignal.2002153A Perspective on Cancer Cell Metastasis
Chaffer, C. L. and Weinberg, R. A.
Science 331
(25 March 2011); doi: 10.1126/science.1203543VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC -driven migration
Razorenova, O. V. et al.
Proceedings of the National Academy of Sciences 108
(1 February 2011); doi: 10.1073/pnas.1011777108Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia
Ridky, Todd W, Chow, Jennifer M, Wong, David J and Khavari, Paul A
Nature Medicine 16 1450 - 1455
(21 November 2010); doi: 10.1038/nm.2265Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes
Scott, Kenneth L. et al.
Cancer Cell 20
(1 July 2011); doi: 10.1016/j.ccr.2011.05.025Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells
Sethi, Nilay, Dai, Xudong, Winter, Christopher G. and Kang, Yibin
Cancer Cell 19
(15 February 2011); doi: 10.1016/j.ccr.2010.12.022CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis CMC
Liu, H. et al.
Proceedings of the National Academy of Sciences 108
(25 January 2011); doi: 10.1073/pnas.1017228108N-α-Acetyltransferase 10 Protein Suppresses Cancer Cell Metastasis by Binding PIX Proteins and Inhibiting Cdc42/Rac1 Activity
Hua, Kuo-Tai et al.
Cancer Cell 19
(15 February 2011); doi: 10.1016/j.ccr.2010.11.010Amphiregulin Exosomes Increase Cancer Cell Invasion
Higginbotham, James N. et al.
Current Biology 21
(1 May 2011); doi: 10.1016/j.cub.2011.03.043CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3
Chen, Jingqi et al.
Cancer Cell 19
(1 April 2011); doi: 10.1016/j.ccr.2011.02.006The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1
Lander, R., Nordin, K. and Labonne, C.
The Journal of Cell Biology 194
(11 July 2011); doi: 10.1083/jcb.201012085Phosphoinositide 3-kinase signaling pathway mediated by p110 regulates invadopodia formation
Yamaguchi, H. et al.
The Journal of Cell Biology 193
(27 June 2011); doi: 10.1083/jcb.201009126Malignant cells facilitate lung metastasis by bringing their own soil
Duda, D. G. et al.
Proceedings of the National Academy of Sciences 107
(14 December 2010); doi: 10.1073/pnas.1016234107Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'
Lin, G., Aranda, V., Muthuswamy, S. K. and Tonks, N. K.
Genes & Development 25
(1 July 2011); doi: 10.1101/gad.2018911Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer
Roussos, E. T. et al.
Journal of Cell Science 124
(1 July 2011); doi: 10.1242/jcs.086231Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-G q coupling
Kim, E.-S. et al.
Journal of Cell Science 124
(1 July 2011); doi: 10.1242/jcs.076794p53 and its mutants in tumor cell migration and invasion
Muller, P. A. J., Vousden, K. H. and Norman, J. C.
The Journal of Cell Biology 192
(24 January 2011); doi: 10.1083/jcb.201009059microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C
Penna, Elisa et al.
The EMBO Journal 30 1990 - 2007
(5 April 2011); doi: 10.1038/emboj.2011.102Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization
Slorach, E. M., Chou, J. and Werb, Z.
Genes & Development 25
(1 March 2011); doi: 10.1101/gad.1998111Cell-surface Receptor for Complement Component C1q (gC1qR) Is a Key Regulator for Lamellipodia Formation and Cancer Metastasis
Kim, K.-B. et al.
Journal of Biological Chemistry 286
(1 July 2011); doi: 10.1074/jbc.M111.233304Characterization of Basigin Isoforms and the Inhibitory Function of Basigin-3 in Human Hepatocellular Carcinoma Proliferation and Invasion
Liao, C.-G. et al.
Molecular and Cellular Biology 31
(1 July 2011); doi: 10.1128/MCB.05160-11Regulation of Lung Cancer Cell Migration and Invasion by Reactive Oxygen Species and Caveolin-1
Luanpitpong, S. et al.
Journal of Biological Chemistry 285
(10 December 2010); doi: 10.1074/jbc.M110.124958The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis
Fu, Junjiang et al.
Cell Research 21 275 - 289
(17 August 2010); doi: 10.1038/cr.2010.118FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers
Tang, Yunneng et al.
Cell Research 21 316 - 326
(7 September 2010); doi: 10.1038/cr.2010.126Rap1-GTP-interacting Adaptor Molecule (RIAM) Protein Controls Invasion and Growth of Melanoma Cells
Hernandez-varas, P. et al.
Journal of Biological Chemistry 286
(27 May 2011); doi: 10.1074/jbc.M110.189811Cancer Cell-Associated MT1-MMP Promotes Blood Vessel Invasion and Distant Metastasis in Triple-Negative Mammary Tumors
Perentes, J. Y. et al.
Cancer Research 71
(1 July 2011); doi: 10.1158/0008-5472.CAN-10-4376Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines
Swaminathan, V. et al.
Cancer Research
(3 June 2011); doi: 10.1158/0008-5472.CAN-11-0247Phosphorylation of Serine 68 of Twist1 by MAPKs Stabilizes Twist1 Protein and Promotes Breast Cancer Cell Invasiveness
Hong, J. et al.
Cancer Research 71
(1 June 2011); doi: 10.1158/0008-5472.CAN-10-2914Diosgenin, a Steroidal Saponin, Inhibits Migration and Invasion of Human Prostate Cancer PC-3 Cells by Reducing Matrix Metalloproteinases Expression
Chen, Pin-Shern et al.
PLoS ONE 6
(23 May 2011); doi: 10.1371/journal.pone.0020164From the Cover: Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape
Liu, L. et al.
Proceedings of the National Academy of Sciences 108
(26 April 2011); doi: 10.1073/pnas.1102808108Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation
Hiratsuka, S. et al.
Proceedings of the National Academy of Sciences 108
(1 March 2011); doi: 10.1073/pnas.1100446108Cancer Cells Cut Homophilic Cell Adhesion Molecules and Run
Craig, S. E. L. and Brady-kalnay, S. M.
Cancer Research 71
(15 January 2011); doi: 10.1158/0008-5472.CAN-10-2301Chemotaxis in cancer
Roussos, Evanthia T., Condeelis, John S. and Patsialou, Antonia
Nature Reviews Cancer 11 573 - 587
(22 July 2011); doi: 10.1038/nrc3078Cancer to bone: a fatal attraction
Weilbaecher, Katherine N., Guise, Theresa A. and Mccauley, Laurie K.
Nature Reviews Cancer 11 411 - 425
(19 May 2011); doi: 10.1038/nrc3055Ligand-independent activation of c-Met by fibronectin and α5β1-integrin regulates ovarian cancer invasion and metastasis
Mitra, A K et al.
Oncogene 30 1566 - 1576
(29 November 2010); doi: 10.1038/onc.2010.532Cancer Cell Migration: Integrated Roles of Matrix Mechanics and Transforming Potential
Baker, Erin L. et al.
PLoS ONE 6
(27 May 2011); doi: 10.1371/journal.pone.0020355DLC1 Interaction with S100A10 Mediates Inhibition of In Vitro Cell Invasion and Tumorigenicity of Lung Cancer Cells through a RhoGAP-Independent Mechanism
Yang, X., Popescu, N. C. and Zimonjic, D. B.
Cancer Research 71
(15 April 2011); doi: 10.1158/0008-5472.CAN-10-2158Interactions Between Laminin Receptor and the Cytoskeleton During Translation and Cell Motility
Venticinque, Lisa, Jamieson, Kelly V., Meruelo, Daniel and Parsons, Maddy
PLoS ONE 6
(7 January 2011); doi: 10.1371/journal.pone.0015895Full-Length L1CAM and Not Its Δ2Δ27 Splice Variant Promotes Metastasis through Induction of Gelatinase Expression
Hauser, Stephanie et al.
PLoS ONE 6
(25 April 2011); doi: 10.1371/journal.pone.0018989The physics of cancer: the role of physical interactions and mechanical forces in metastasis
Wirtz, Denis, Konstantopoulos, Konstantinos and Searson, Peter C.
Nature Reviews Cancer 11 512 - 522
(24 June 2011); doi: 10.1038/nrc3080Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling
Tan, Wei et al.
Nature 470 548 - 553
(16 February 2011); doi: 10.1038/nature09707Mouse models of advanced spontaneous metastasis for experimental therapeutics
Francia, Giulio et al.
Nature Reviews Cancer 11 135 - 141
(24 January 2011); doi: 10.1038/nrc3001Differential Expressions of Adhesive Molecules and Proteases Define Mechanisms of Ovarian Tumor Cell Matrix Penetration/Invasion
Kwon, Youngjoo, Cukierman, Edna, Godwin, Andrew K. and Orsulic, Sandra
PLoS ONE 6
(19 April 2011); doi: 10.1371/journal.pone.0018872CKIα ablation highlights a critical role for p53 in invasiveness control
Elyada, Ela et al.
Nature 470 409 - 413
(16 February 2011); doi: 10.1038/nature09673Solving the Puzzle of Metastasis: The Evolution of Cell Migration in Neoplasms
Chen, Jun et al.
PLoS ONE 6
(27 April 2011); doi: 10.1371/journal.pone.0017933SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression
Ding, Zhihu et al.
Nature 470 269 - 273
(2 February 2011); doi: 10.1038/nature09677IL-6 Stabilizes Twist and Enhances Tumor Cell Motility in Head and Neck Cancer Cells through Activation of Casein Kinase 2
Su, Ying-Wen et al.
PLoS ONE 6
(29 April 2011); doi: 10.1371/journal.pone.0019412The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
Liu, Can et al.
Nature Medicine 17 211 - 215
(16 January 2011); doi: 10.1038/nm.2284Tyrosine 23 Phosphorylation-Dependent Cell-Surface Localization of Annexin A2 Is Required for Invasion and Metastases of Pancreatic Cancer
Zheng, Lei et al.
PLoS ONE 6
(29 April 2011); doi: 10.1371/journal.pone.0019390Nucleating actin for invasion
Nürnberg, Alexander, Kitzing, Thomas and Grosse, Robert
Nature Reviews Cancer 11 177 - 187
(10 February 2011); doi: 10.1038/nrc3003Simultaneous siRNA Targeting of Src and Downstream Signaling Molecules Inhibit Tumor Formation and Metastasis of a Human Model Breast Cancer Cell Line
Bjorge, Jeffrey D. et al.
PLoS ONE 6
(26 April 2011); doi: 10.1371/journal.pone.0019309Novel roles for Slits and netrins: axon guidance cues as anticancer targets?
Mehlen, Patrick, Delloye-bourgeois, Céline and Chédotal, Alain
Nature Reviews Cancer 11 188 - 197
(17 February 2011); doi: 10.1038/nrc3005The calpain system and cancer
Storr, Sarah J. et al.
Nature Reviews Cancer 11 364 - 374
(21 April 2011); doi: 10.1038/nrc3050