Welcome to the May 2013 Cell Migration Update, your one-stop resource for news, highlights and research on cell migration.
CELL MIGRATION @ NATURE.COM
A comprehensive library of the latest research related to cell migration
PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis
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Nature Communications
FEATURED ARTICLES
Editor's reviews of the hottest new articles
HER2 in the DOCK over breast cancer metastasis
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Activation of the Rac GEF DOCK1 downstream of HER2 increases Rac activity to promote the migration of breast cancer cells and facilitate breast cancer metastasis in vivo.
Original research paper: Proc. Natl Acad. Sci. USA, published online 16 April 2013
Two-leg trip to invasion
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A novel pathway involving HIF-1α, Notch, ADAM12 and HB-EGF promotes the formation of invadopodia in hypoxia.
Original research paper: J. Cell Biol. 201, 279–292 (2013)
CONSORTIUM NEWS
The latest news from the CMC
β1 integrin’s importance in invadopodia
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Other CMC Publications
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CELL MIGRATION KNOWLEDGEBASE
Visit the Cell Migration Knowledgebase for the latest cell migration protein database entries.
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CONSORTIUM ACTIVITIES
Find out more about the Consortium activities, and the latest Consortium Updates.
RESEARCH HIGHLIGHTS
Synopses of important recent articles
Ovarian cancer: Driving force
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Actomyosin-mediated contractility in ovarian cancer cells induces mesothelial cells to de-adhere and move away, facilitating penetration of the mesothelial barrier during metastasis.
Nature Reviews Cancer 11, 538 - 539 (2011)
Innate immunity: Neutrophil U-turn fans the flames
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The expression of junctional adhesion molecule C in endothelial cells is required to prevent reverse transendothelial migration of neutrophils.
Nature Reviews Immunology 11, 498 (2011)