Research Highlights
This is an archive of research highlights generated between June 2005 and August 2011. These highlights summarize and put into context must-read papers related to cell migration.
July 2011
Mechanotransduction: YAP and TAZ feel the force
Standfirst
ECM stiffness and cell spreading influence the nuclear localization of YAP and TAZ through a pathway that requires Rho and cytoskeletal tension.
Nature Reviews Molecular Cell Biology 12, 404 - 405 (2011)doi:10.1038/nrm3136
Tumour immunology: MDSCs come at a cost
Standfirst
Increased numbers and suppressive activity of myeloid-derived suppressor cells during pregnancy results in reduced natural killer cell cytotoxicity and increased tumour dissemination.
Nature Reviews Immunology 11, 440 - 441 (2011)doi:10.1038/nri3017
Signalling: Location, location, location
Standfirst
Blocking endocytosis reduced cell migration and lung colonization and metastasis of fibroblasts expressing constitutively active MET receptor tyrosine kinase mutants.
Nature Reviews Cancer 11, 462 - 463 (2011)doi:10.1038/nrc3096
Metastasis: New recruits
Standfirst
Antibodies against the chemokine CCL2 block the recruitment of inflammatory monocytes to metastatic sites following tumour cell injection.
Nature Reviews Cancer 11, 462 - 463 (2011)doi:10.1038/nrc3100