Featured Articles
Each month we showcase exciting new cell migration articles from the literature.
July 2011
RasGRFs identified as shapeshifters
Standfirst
RasGRFs compete with Cdc42 GEFs for Cdc42 binding to regulate the activity of this Rho GTPase and influence the mode of cell movement.
Original research paper: Nature Cell Biol., published online 19 June 2011
Many (converging) pathways, one destination: forwards!
Standfirst
The RhoGAP SH3BP1 interacts with the exocyst to inactivate Rac1 at the leading edge, contributing to a Rac1 activation–inactivation cycle that drives cell migration.
Original research paper: Mol. Cell 42, 650-661 (2011)