Research Highlights
This is an archive of research highlights generated between June 2005 and August 2011. These highlights summarize and put into context must-read papers related to cell migration.
June 2011
Cytoskeleton: RhoC invades cofilin's space
Standfirst
RhoC promotes cofilin phosphorylation around, but not inside, invadopodia to restrict its actin-severing activity to the invadopodial core.
Nature Reviews Molecular Cell Biology 12, 346 - 347 (2011)doi:10.1038/nrm3128
Monocytes: Nudged out of the niche
Standfirst
Stromal cells respond to TLR ligands by promoting the emigration of monocytes from bone marrow niches during infection.
Nature Reviews Immunology 11, 368 - 369 (2011)doi:10.1038/nri2999
Animal models: Mastering RNAi in mice
Standfirst
An economical and efficient approach to generating mice that express short hairpin RNAs (shRNAs), which trigger RNAi, is outlined.
Nature Reviews Genetics 12, 380 (2011)doi:10.1038/nrg3004
Bacterial physiology: Motor helps gliders to gain traction
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Gliding motility in Myxococcus xanthus is driven by membrane-bound motor complexes that are coupled to the cytoskeleton and the substratum.
Nature Reviews Microbiology 9, 398 (2011)doi:10.1038/nrmicro2579
Cancer: Lipoxygenase makes a leaky tumour
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The eicosanoid 12(S)-HETE might facilitate the passage of tumour cells through the lymphatic system by creating defects in the endothelium surrounding it.
Nature Reviews Drug Discovery 10, 414 (2011)doi:10.1038/nrd3469