Research Highlights
This is an archive of research highlights generated between June 2005 and August 2011. These highlights summarize and put into context must-read papers related to cell migration.
February 2011
Cytoskeleton: N-WASP 'muscles in' on actin nucleation
Standfirst
N-WASP and nebulin induce actin polymerization independently of ARP2/3 in myofibrils in response to insulin-like growth factor 1.
Nature Reviews Molecular Cell Biology 12, 73 (2011)doi:10.1038/nrm3045
Cell signalling: Targeting kinases
Standfirst
Kinase-associated 1 (KA1) domain is identified as a novel phospholipid-binding domain that targets kinases to the plasma membrane.
Nature Reviews Molecular Cell Biology 12, 75 (2011)doi:10.1038/nrm3055
Lymphocyte migration: Travel agents for two
Standfirst
Extracellular matrix protein 1 is shown to be required for T helper 2 cells to exit lymphoid tissues, whereas CC-chemokine receptor 8 facilitates their migration to allergen-inflamed skin.
Nature Reviews Immunology 11, 77 (2011)doi:10.1038/nri2927
Signalling: REX rules
Standfirst
PREX1, a guanine nucleotide exchange factor for RAC, integrates signals from tyrosine kinase receptors and
G protein-coupled receptors to activate RAC1, inducing proliferation and migration in breast cancer cells.Nature Reviews Cancer 11, 83 (2011)doi:10.1038/nrc3013
Cancer: Hope for smoking-associated lung cancer?
Standfirst
Fibroblast growth factor receptor 1 is identified as a promising new molecular target for the treatment of smoking-associated lung cancer.
Nature Reviews Drug Discovery 10, 98 - 99 (2011)doi:10.1038/nrd3378