Research Highlights
This is an archive of research highlights generated between June 2005 and August 2011. These highlights summarize and put into context must-read papers related to cell migration.
December 2010
Innate immunity: Neutrophil recruitment on the big screen
Standfirst
The recruitment of neutrophils to sites of sterile inflammation involves a multistep pathway.
Nature Reviews Immunology 10, 807 (2010)doi:10.1038/nri2892
Cytoskeleton: Keeping minus ends stable
Standfirst
Patronin stabilizes the minus ends of microtubules by binding to them and protecting them against depolymerization.
Nature Reviews Molecular Cell Biology 11, 816 (2010)doi:10.1038/nrm3014
Bacterial pathogenicity: Formin' a comet tail
Standfirst
Many Rickettsia species rely on the formin-like protein Sca2, rather than on Arp2/3 and RickA, to mediate actin nucleation thereby forming comet tails.
Nature Reviews Microbiology 8, 837 (2010)doi:10.1038/nrmicro2481
G protein-coupled receptors: Insights into chemokine receptors
Standfirst
The crystal structure of the chemokine receptor CXCR4, a G protein-coupled receptor that has been implicated in cancer metastasis, has been determined.
Nature Reviews Drug Discovery 9, 920 (2010)doi:10.1038/nrd3331