Research Highlights
This is an archive of research highlights generated between June 2005 and August 2011. These highlights summarize and put into context must-read papers related to cell migration.
October 2010
Metastasis: Twisting BMI1
Standfirst
The transcription factor TWIST1 directly targets BMI1; both proteins are required to induce EMT and stem-cell-like properties that are important for tumour progression.
Nature Reviews Cancer 10, 666 - 667 (2010)doi:10.1038/nrc2940
The limits of light
Standfirst
Super-resolution microscopy has provided insights into the organization and function of complex subcellular structures, such as focal adhesions, not previously achievable by conventional or confocal light microscopy.
Nature Reviews Molecular Cell Biology 11, 678 (2010)doi:10.1038/nrm2989
Autoimmunity: Get me to the joint on time
Standfirst
Neutrophil recruitment to joints during arthritis requires a lipid-cytokine-chemokine recruitment cascade.
Nature Reviews Immunology 10, 678 - 679 (2010)doi:10.1038/nri2857
Environment dictates behaviour
Standfirst
The physical properties of the ECM extend beyond a supportive structural role and can profoundly influence cell behaviour.
Nature Reviews Molecular Cell Biology 11, 679 (2010)doi:10.1038/nrm2984
Sensing and controlling protein dynamics
Standfirst
The use of biosensors and photoactivatable proteins has led to the discovery of valuable information about the dynamics of small GTPases in living cells.
Nature Reviews Molecular Cell Biology 11, 680 - 681 (2010)doi:10.1038/nrm2985