Research Highlights
Short, accessible highlights that summarize and put into context must-read papers related to cell migration.
February 2010
To adhere or not to adhere?
Standfirst
Non-adhesive cell migration in 3D tissues.
Nature Reviews Molecular Cell Biology 11, 3 (2010)doi:10.1038/nrm2825
Signalling: Different strokes
Standfirst
Ephβ receptors regulate cell proliferation and migration through two distinct downstream signalling pathways, which present potential drug targets for the treatment of familial adenomatous polyposis (FAP).
Nature Reviews Cancer 10, 4 (2010)doi:10.1038/nrc2777
Development: Tension at the borders
Standfirst
Regulation of actomyosin-dependent cortical tension is important to maintain boundaries in proliferating tissues.
Nature Reviews Molecular Cell Biology 11, 4 - 5 (2010)doi:10.1038/nrm2827
Metastasis: Self-renewal migrates onwards
Standfirst
Expression of ZEB1 in cancer cells enables epithelial to mesenchymal transition (EMT) and stem-cell like properties, forming migrating tumour stem cells.
Nature Reviews Cancer 10, 6 - 7 (2010)doi:10.1038/nrc2778
Endocytosis: WASHed and sorted
Standfirst
WASP and SCAR homologue (WASH) regulates actin polymerization, cytoskeletal reorganization and subsequent changes in cell morphology.
Nature Reviews Molecular Cell Biology 11, 6 - 7 (2009)doi:10.1038/nrm2819
