Research Highlights
Short, accessible highlights that summarize and put into context must-read papers related to cell migration.
August 2009
Cancer biology: WAVEing goodbye to invasion
Standfirst
A new study shows that reduced expression of a subunit of the actin dynamics regulatory complex WAVE - cytoplasmic FMR1 interacting protein 1 (CYFIP1) - causes loss of epithelial cell adhesion and promotes tumour progression.
Nature Reviews Molecular Cell Biology 10, 506 - 507 (2009)doi:10.1038/nrm2732
Metastasis: T-ALL order
Standfirst
CCR7 has been identified as a chemokine receptor crucial for central nervous system (CNS) infiltration, paving the way for reducing the toxicity of treatments used to prevent CNS relapse in patients diagnosed with T-cell acute lymphoblastic leukaemia (T-ALL).
Nature Reviews Cancer 9, 531 (2009)doi:10.1038/nrc2701
Innate immunity: Endothelial cells as sentinels
Standfirst
A new study shows that endothelial cells are the key sentinel cells for detecting infection by Gram-negative bacteria and recruiting neutrophils to peripheral tissues.
Nature Reviews Immunology 9, 532 - 533 (2009)doi:10.1038/nri2608
