Research Highlights
Short, accessible highlights that summarize and put into context must-read papers related to cell migration.
July 2009
Coronin switches roles in actin disassembly depending on the nucleotide state of actin
Standfirst
It has been shown that whether coronin inhibits or promotes cofilin-mediated actin disassembly depends on the nucleotide state of actin.
Nature Reviews Molecular Cell Biology 10, 441 (2009)doi:10.1038/nrm2723
p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of slug
Standfirst
A new study shows that one of numerous functions of the tumour suppressor p53 might be to limit the invasive potential of cells through the regulation of the transcription factor slug.
Nature Reviews Cancer 9, 459 (2009)doi:10.1038/nrc2690
Breast cancer: Metastasis on the brain
Standfirst
A new study shows that breast cancer metastasis to the brain usually occurs after metastasis to other organs because cells must be capable of not only general extravasation but also of passing through the blood-brain barrier.
Nature Reviews Cancer 9, 460 - 461 (2009)doi:10.1038/nrc2678
