Research Highlights
Short, accessible highlights that summarize and put into context must-read papers related to cell migration.
June 2009
Metastasis: Attack of the mutant p53
Standfirst
A new pathway that suggests opposing roles for mutant p53 and wild-type p63 in the promotion of metastasis by transforming growth factor-β (TGFβ) has been described, uncovering a gene signature that could be clinically useful for predicting breast cancer prognosis.
Nature Reviews Cancer 9, 384 - 385 (2009)doi:10.1038/nrc2658
Neuroimmunology: Finding a way into the brain
Standfirst
A new study shows that the initiation of experimental autoimmune encephalitis — an inflammatory demyelinating disease used as a model for multiple sclerosis — is controlled by CC-chemokine receptor 6 (CCR6)-dependent entry of T helper 17 (TH17) cells into the central nervous system through the choroid plexus.
Nature Reviews Immunology 9, 386 (2009)doi:10.1038/nri2549
Neuroimmunology: Basement membrane laminins guard the CNS
Standfirst
Recent research indicates that basement membrane laminins specifically regulate the migration of myelin-specific CD4+ T cells from the blood into the central nervous system, which could lead to more specific therapies for multiple sclerosis.
Nature Reviews Immunology 9, 391 (2009)doi:10.1038/nri2576
Neuronal migration: You have arrived
Standfirst
Changes in the response of cortical interneurons to extracellular GABA (γ-aminobutyric acid) as a result of upregulation of the K+-Cl- co-transporter KCC2 (also known as SLC12A5) have been shown to halt interneuron migration.
Nature Reviews Neuroscience 10, 394 - 395 (2009)doi:10.1038/nrn2654
