Research Highlights
Short, accessible highlights that summarize and put into context must-read papers related to cell migration.
May 2009
Cytoskeleton: JMY: actin up in cell motility
Standfirst
The p53 cofactor JMY has been identified as a novel actin nucleation factor that promotes cell motility.
Nature Reviews Molecular Cell Biology 10, 304 (2009)doi:10.1038/nrm2678
T cell development: Open sesame! Thymic entry commands revealed
Standfirst
The commands controlling the entry of T cell progenitors from the blood to the thymus - which occurs in waves via a 'gated' process - have been shown to originate from occupied thymic niches and the peripheral lymphocyte pool.
Nature Reviews Immunology 9, 305 (2009)doi:10.1038/nri2561
Funding watch: Cash injection for US research
Standfirst
In an era of global economic downturn, scientific research in the United States has received a boost with the receipt of approximately US$20 billion in investment money.
Nature Reviews Immunology 9, 306 (2009)doi:10.1038/nri2562
Regulatory T cells: Taking the right route
Standfirst
A new study shows that regulatory T (TReg) cells - which suppress unwanted immune responses - migrate from inflamed tissues to the draining lymph nodes in an islet allograft model and that this migration pattern is necessary for their suppressive function and islet graft survival.
Nature Reviews Immunology 9, 311 (2009)doi:10.1038/nri2556
