Research Highlights
Short, accessible highlights that summarize and put into context must-read papers related to cell migration.
June 2008
Metastasis: Regressing to self-renewal
Standfirst
New findings show that the epithelial-mesenchymal transition confers stem cell-like properties as well as being adopted by tumour cells to acquire malignant traits such as survival and invasiveness.
Nature Reviews Cancer 8, 483 (2008)doi:10.1038/nrc2423
Cancer genetics: Looking at the big picture
Standfirst
A large-scale mutagenesis screen in mice reveals the networks that link candidate oncogenes and tumour suppressors. The results are available as an online resource (http://mutapedia.nki.nl) that will allow researchers to validate these interactions and investigate specific ones in more detail.
Nature Reviews Genetics 9, 498 - 499 (2008)doi:10.1038/nrg2405
Cell morphology: Breaking the spatial code
Standfirst
A new quantitative physical model explaining cell shape and movement has been developed based on measurements of motile fish keratocytes.
Nature Reviews Molecular Cell Biology 9, 500 (2008)doi:10.1038/nrm2433
