Research Highlights
Short, accessible highlights that summarize and put into context must-read papers related to cell migration.
June 2008
Regulatory T cells: Lending a hand to protective immunity
Standfirst
Regulatory T (TReg) cells were unexpectedly found to promote early protective immune responses by allowing the timely entry of immune cells to infected tissues.
Nature Reviews Immunology 8, 402 - 403 (2008)doi:10.1038/nri2352
Metastasis: Trading in mitochondria
Standfirst
Common mitochondrial DNA mutations, such as those associated with reactive oxygen species overproduction, increase the metastatic potential of tumour cell lines.
Nature Reviews Cancer 8, 409 (2008)doi:10.1038/nrc2411
Metastasis: Which way to the lungs?
Standfirst
A set of 153 transforming growth factor beta (TGF beta) target genes - the TGF beta response signature (TBRS) - were shown to control both the effect of cytokines on tumour development and the capacity of breast cancer cells to metastasize to the lungs.
Nature Reviews Cancer 8, 410 - 411 (2008)doi:10.1038/nrc2410
Cell signalling: Dynamic redistribution
Standfirst
The non-canonical WNT5a pathway controls cell polarity and directional motility by redistributing adhesion receptors via a cell-autonomous mechanism.
Nature Reviews Molecular Cell Biology 9, 423 (2008)doi:10.1038/nrm2413
Cell migration: The importance of being selective
Standfirst
The phosphoinositide 3-kinase (PI3K) p110alpha functions specifically during angiogenesis, acting downstream of vascular endothelial growth factor A to promote proliferation, migration and survival of endothelial cells.
Nature Reviews Molecular Cell Biology 9, 426 - 427 (2008)doi:10.1038/nrm2422
