Research Highlights
Short, accessible highlights that summarize and put into context must-read papers related to cell migration.
May 2008
Tumour microenvironment: No changes necessary
Standfirst
The lack of genetic alterations in carcinoma-associated fibroblasts suggests that the role of the tumour microenvironment in driving tumorigenesis may depend on epigenetic rather than somatic changes in stromal cells.
Nature Reviews Cancer 8, 324 - 325 (2008)doi:10.1038/nrc2384
Oncogenes: Sibling rivalry explained
Standfirst
The use of genetically engineered mice has shed light on the distinct effects of proteins encoded by the oncogenes KRAS and NRAS on differentiation and tumorigenesis in colonic epithelium.
Nature Reviews Cancer 8, 324 - 325 (2008)doi:10.1038/nrc2385
Cell migration: Group voyage
Standfirst
Collective cell migration is regulated by an evolutionarily conserved cascade that involves the Jun N-terminal kinase (JNK) signalling pathway.
Nature Reviews Molecular Cell Biology 9, 346 (2008)doi:10.1038/nrm2405
