Research Highlights
Short, accessible highlights that summarize and put into context must-read papers related to cell migration.
February 2008
Drug resistance: Destabilizing influence
Standfirst
Loss of the extracellular matrix protein TGFβI (transforming growth factor β-induced) in ovarian cancers modulates the response to the chemotherapeutic agent paclitaxel.
Nature Reviews Cancer 8, 76 - 77 (2008)doi:10.1038/nrc2316
Nanotechnology: Drawing tumour cells from blood
Standfirst
A new microfluidic chip that can isolate the circulating tumour cells found in the blood of cancer patients at low concentrations may provide new possibilities for both diagnosis and understanding the biology of metastasis.
Nature Reviews Cancer 8, 81 (2008)doi:10.1038/nrc2317
Tumour immunology: TGF
betrays immunity for tumorigenesisStandfirst
The recruitment of immature myeloid cells to tumours may determine the switch between an anti-tumorigenic and a pro-tumorigenic function for transforming growth factor-β in the tumour microenvironment.
Nature Reviews Immunology 8, 89 (2008)doi:10.1038/nri2263
Tumour immunotherapy: Little pig, little pig, let me come in
Standfirst
A new mechanism by which the tumour endothelium blocks T-cell homing has been identified, which may be overcome to enhance the efficacy of tumour immunotherapy.
Nature Reviews Immunology 8, 90 - 91 (2008)doi:10.1038/nri2265
