Research Highlights
This is an archive of research highlights generated between June 2005 and August 2011. These highlights summarize and put into context must-read papers related to cell migration.
January 2008
Cell migration: Immunosurveillance by recirculating HSPCs
Standfirst
Migratory haematopoietic stem and progenitor cells traffic from the bone marrow to survey non-lymphoid peripheral organs and boost the local supply of immune effector cells.
Nature Reviews Immunology 8, 2 (2008)doi:10.1038/nri2242
Tumour suppressors: Keeping Trim
Standfirst
The tumour-suppressor gene tripartate motif-containing 24 (Trim24) regulates the retinoic acid transcriptional network and restricts the formation of hepatocellular carcinoma in mice.
Nature Reviews Cancer 8, 8 - 9 (2008)doi:10.1038/nrc2300
Therapeutics: Attacked from all sides
Standfirst
TAE226 is a small molecule inhibitor of focal adhesion kinase that is effective against the development and metastasis of ovarian cancer in mice.
Nature Reviews Cancer 8, 8 (2008)doi:10.1038/nrc2304