Featured Articles
Each month we showcase exciting new cell migration articles from the literature.
January 2008
EGF signalling: The GEP100 pathway to invasion
Standfirst
When stimulated by epidermal growth factor (EGF), the guanine nucleotide-exchange factor GEP100 interacts with the EGF receptor (EGFR) to specifically activate the Arf6 GTPase and induce breast cancer cell invasion.
Original research paper: Nat. Cell Biol. 10, 85-92 (2008)
EGF and PIP2 hydrolysis: Cofilin set free
Standfirst
An EGF-induced drop in phosphatidylinositol 4,5-bisphosphate levels activates cofilin by releasing it from the plasma membrane, thus allowing actin polymerisation and cell protrusion in mammary tumour cells.
Original research paper: J. Cell Biol. 179, 1247-1259 (2008)