Featured Articles
Each month we showcase exciting new cell migration articles from the literature. Access to featured primary research articles from journals in the Nature family is free for three months.
January 2008
EGF signalling: The GEP100 pathway to invasion
Standfirst
When stimulated by epidermal growth factor (EGF), the guanine nucleotide-exchange factor GEP100 interacts with the EGF receptor (EGFR) to specifically activate the Arf6 GTPase and induce breast cancer cell invasion.
Original research paper: Nat. Cell Biol. 10, 85-92 (2008)
EGF and PIP2 hydrolysis: Cofilin set free
Standfirst
An EGF-induced drop in phosphatidylinositol 4,5-bisphosphate levels activates cofilin by releasing it from the plasma membrane, thus allowing actin polymerisation and cell protrusion in mammary tumour cells.
Original research paper: J. Cell Biol. 179, 1247-1259 (2008)