Research Highlights
Short, accessible highlights that summarize and put into context must-read papers related to cell migration.
September 2007
Lung cancer: Expanding the range
Standfirst
The serine/threonine kinase LKB1 suppresses lung cancer by inhibiting tumour initiation and metastasis, making it a potential prognostic marker of aggressive disease, as well as making its substrates potential targets for new therapeutic strategies.
Nature Reviews Cancer 7, 642 - 643 (2007)doi:10.1038/nrc2220
Chemokines: Dictating migration
Standfirst
The transient downregulation of homeostatic chemokines affects lymphocyte and dendritic cell accumulation during immune responses, which promotes the generation of memory T-cells.
Nature Reviews Immunology 7, 663 (2007)doi:10.1038/nri2159
Networks: The complexity of adhesion
Standfirst
A detailed description of the in silico mammalian integrin adhesome network gives further insights into how adhesion sites are formed and regulated, and how cells sense their environment.
Nature Reviews Molecular Cell Biology 8, 674 - 675 (2007)doi:10.1038/nrm2237
Cell polarity: Acquiring direction from new contacts
Standfirst
A mechanistic link between the basolateral membrane domain and cell-cell contact formation suggests that cell adhesion may regulate the establishment of cell polarity.
Nature Reviews Molecular Cell Biology 8, 678 (2007)doi:10.1038/nrm2244
