Research Highlights
Short, accessible highlights that summarize and put into context must-read papers related to cell migration.
July 2007
Finding needles in a haystack
Standfirst
Genome-wide association studies have identified several new loci that increase our understanding of the genetics underlying breast cancer risk.
Nature Reviews Cancer 7, 493doi:10.1038/nrc2177
Endocannabinoids steer developing axons
Standfirst
Endocannabinoid signalling drives chemorepulsion and axon guidance of GABA-containing interneurons, and is crucial for the formation of accurate synaptic connections in the developing cortex.
Nature Reviews Neuroscience 8, 493doi:10.1038/nrn2179
An encyclopaedia of interactions
Standfirst
The Pathway Interaction Database provides a simple web interface for finding key information about known biomolecular interactions and signalling pathways.
Original research paper: Nature Reviews Molecular Cell Biology 8 512 (2007)doi:10.1038/nrm2210
Finding the right target
Standfirst
The phosphatidylinositol 3-kinase (PI3K) subunit p110
ñ has been identified as a Ras effector in both developmental and malignant growth-factor signalling, highlighting the Rasƒ??PI3K interaction as a potential therapeutic target.Nature Reviews Molecular Cell Biology 8, 515doi:10.1038/nrm2209
