Featured Articles
Each month we showcase exciting new cell migration articles from the literature.
April 2007
4 integrin-dependent migration: PKA marches at the frontStandfirst
Results showing that
4 integrins anchor type I-cAMP-dependent protein kinases (PKAs) to the leading edge of the migrating cell reveal a new role for type I PKA in cell migration processes.Original research paper: Nature Cell Biology 9, 415-421 (2007)
Directional cell motility: PIP3 Akts via PDK1
Standfirst
Phosphoinositide-dependent kinase-1 (PDK1) activates AKT/PKB by docking to phosphatidylinositol 3,4,5-trisphosphate (PIP3) during cell migration.
Original research paper: Journal Cell Biology 176, 1035-1047 (2007)