February 2007

• Chemical detectors or polarity cues?

  Two new studies examine the dynamic accumulation of phosphatidylinositol-3,4,5-trisphosphate at the leading edge of primary neutrophils during chemotaxis.

  Original research paper: Nature Reviews Molecular Cell Biology 9, 36-44
  (February 2007); doi:10.1038/nrm2111

• Fat gets picky with macrophages

  In mouse models of atherosclerosis and obesity distinct subsets of monocytes are recruited to lipid-rich tissues.

  Original research paper: Nature Reviews Immunology 7, 87
  (February 2007); doi:10.1038/nri2026

• Breaking and entering

  The transcriptional regulator nuclear factor kappa B (NFB) contributes to osteolytic bone metastasis by inducing the expression of granulocyte–macrophage colony stimulating factor (GMCSF).

  Original research paper: Nature Reviews Cancer 7, 73
  (February 2007); doi:10.1038/nrc2077

• Less is more

  Paradoxically, inhibition of the Notch signalling pathway increases endothelial cell proliferation and tumour vascular density but inhibits tumour growth.

  Original research paper: Nature Reviews Cancer 7, 73
  (February 2007); doi:10.1038/nrc2076