Research Highlights
Short, accessible highlights that summarize and put into context must-read papers related to cell migration.
October 2006
Overcoming the barrier
Two groups have independently developed fluorescence-microscopy techniques that allow nanometre resolution.
Original research paper: Proc. Natl Acad Sci. USA 103, 11440-11445
(2006)Stop–Go signals for T cells
CTLA4 (cytotoxic T-lymphocyte antigen 4) inhibits T-cell activation by overriding the T-cell receptor-mediated stop signal and increasing T-cell motility.
Original research paper: Science,
(24 Aug 2006); doi:10.1126/science.1131078Moving downstream
Inhibition of the Akt–mTOR pathway significantly reduces tumour growth, endothelial Akt activation and the permeability of tumour blood vessels.
Original research paper: Cancer Cell 10, 159-170
(2006)Microarray quality in the spotlight again
The formal reports of the work conducted by the MicroArray Quality Control Consortium (MAQC) evaluate the reliability of DNA microarray data.
Original research paper: Nat. Biotech. , 24, 1151 - 1161
(2006)