June 2006

• Cell adhesion: Anchors away!

  Two IGF-II mRNA-binding proteins, IMP1 and IMP3, are necessary for proper cell adhesion, cytoplasmic spreading and invadopodia formation.

  Original research paper: EMBO J. 25, 1456-1468
  (2006)

• T-cell activation: CCL3 and CCL4 actively recruit CD8⁺ T cells

  CD8⁺ T cells are actively recruited to sites of antigen-specific interactions between CD4⁺ T cells and dendritic cells.

  Original research paper: Nature 440, 890-895
  (2006)

• Metastasis: Stopping the spread

  A new study shows that the enzyme lysyl oxidase (LOX), which is highly expressed in hypoxic tumour cells, is crucial for hypoxia-induced metastasis.

  Original research paper: Nature 440, 1222-1226
  (2006)

• Mouse genetics: No Mickey-Mouse phenomics

  X-ray microscopic computed tomography (microCT) is a novel, rapid, and inexpensive method for obtaining high-resolution virtual histology of transgenic mouse embryos.

  Original research paper: PLoS Genet.,
  2, e61 (2006)