March 2006

• Angiogenesis: Initiation

  A new study shows that bone-marrow-derived cells contribute to angiogenesis by a paracrine process that is initiated by VEGF.

  Original research paper: Cell 124, 175-189
  (2006)

• Neuronal migration: Marching of the neurons

  Signalling molecules streaming in the cerebrospinal fluid (CSF) of the adult brain help newborn neurons reach the olfactory bulb.

  Original research paper: Science 12 January
  (2006)

• Invasive loss

  Reduced expression of the pro-apoptotic enzyme caspase-8 in neuroblastoma cells facilitates the formation of metastases in vivo.

  Original research paper: Nature 439, 95-99
  (2006)

• Genomics: Complete coverage?

  A new method for screening the entire genome for transcription factor binding sites has revealed over 98 novel targets of the tumour suppressor and transcription factor p53.

  Original research paper: Cell 124, 207-219
  (2006)