Research Highlights
Short, accessible highlights that summarize and put into context must-read papers related to cell migration.
November 2005
Metastasis: One step closer
Metastatic proclivity of melanoma is partly attributable to lineage-specific factors expressed in melanocytes.
Original research paper: Nature Genet. 37, 1047-1054
(2005)Developmental biology: Shapely organs require clear orientation
Planar cell polarity genes are required for the proper orientation of cell division and the determination of organ shape in Drosophila.
Original research paper: Curr. Biol. 15, 1640-1644
(2005)Atherosclerosis: Go with the flow
A mechanosensory complex in endothelial cells triggers expression of inflammatory genes in response to shear stress.
Original research paper: Nature 437, 426-431
(2005)Imaging: Seeing the light
Activation of an optical probe by tumour-expressed proteases allows researchers to identify and track lung tumours in mice.
Original research paper: Proc. Natl Acad. Sci. USA 102, 14404-14409
(2005)Tumour homeostasis: Newton's third law
Matrix stiffness promotes epithelial cell malignancy by clustering integrins, enhancing ERK activation and increasing ROCK-generated contractility.
Original research paper: Cancer Cell 8, 241-254
(2005)