Research Highlights
Short, accessible highlights that summarize and put into context must-read papers related to cell migration.
August 2005
Mouse models: Knocking in is the new knocking out
The Trp53k1/k1 mouse expresses a p53 protein which is regulated by an artificial ligand, providing greater insight into p53 function
Original research paper: Nature Genet. 37, 718-726
(2005)Angiogenesis: All tied up
Different forms of Vascular endothelial growth factor (VEGF) have been found to promote the disorganised patterning of tumour blood vessels.
Original research paper: J. Cell Biol. 169, 681–691
(2005); doi:10.1083/jbc.200409115Structural biology: Spirals and curls
The X-ray structure of vinblastine-bound tubulin helps explain the effects of vinblastine on microtubule dynamics.
Original research paper: Nature 435, 519-522
(2005)Tumour immunology: B cells lead the way in tumour progression
New mouse model reveals a role for B cell-induced chronic inflammation in carcinogenesis.
Original research paper: Cancer Cell 7, 411-423
(2005)