Consortium Updates
Welcome to the Cell Migration Consortium's updates page, where we highlight major additions of data and information, and outline some of the publications appearing as a result of the Consortium's activities.
Archived Consortium Updates
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November 2004
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Image Correlation Microscopy
Image Correlation Microscopy (ICM) was used to develop cellular maps of integrin clustering, diffusion and interactions in the cell. Two color ICM shows that alpha5 integrin and alpha-actinin localize and move together even in regions of the cell with no discernable adhesions.
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Wiseman PW, Brown CM, Webb DJ, Hebert B, Johnson NL, Squier JA, Ellisman MH, Horwitz AF. Spatial mapping of integrin interactions and dynamics during cell migration by Image Correlation Microscopy. J Cell Sci.
2004 Nov 1;117(Pt 23):5521-34. Epub 2004 Oct 12. PubMed.
October 2004
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Visualization of endogenous Cdc42 activation in living cells.
A novel domain-environment sensitive fluorophore allows the visualization of endogenous Cdc42 activation in living cells.
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Nalbant P, Hodgson L, Kraynov V, Toutchkine A, Hahn KM. Activation of endogenous
Cdc42 visualized in living cells. Science. 2004 Sep 10;305(5690):1615-9. PubMed
July 2004
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Structural basis of Vinculin activation
High resolution structural analysis reveals the basis for vinculin activation.
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Bakolitsa C, Cohen DM, Bankston LA, Bobkov AA, Cadwell GW, Jennings L, Critchley DR, Craig
SW, Liddington RC. Structural basis for vinculin activation at sites of cell adhesion. Nature.
2004 Jul 29;430(6999):583-6. Epub 2004 Jun 13.
PubMed