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December 2002

• Adhesion and cytoskeletal molecules get the Green light

  In a publication in the November edition of Current Biology, the Horwitz laboratory describes a GFP based expression cloning strategy to identify novel adhesion and cytoskeletal molecules and in so doing described the identification of a novel microtubule-associated protein that regulates microtubule organization and cytokinesis.

  Manabe R, Whitmore L, Weiss JM, Horwitz AR. Identification of a novel microtubule-associated protein that regulates microtubule organization and cytokinesis by using a GFP-screening strategy. Curr Biol. 2002 Nov 19;12(22):1946-51. PubMed

October 2002

• Publication Highlights

  Reviews on the structural basis of integrin activation and their role as bidirectional, allosteric signaling machines.

  1. Liddington RC, Ginsberg MH. Integrin activation takes shape. J Cell Biol. 2002 Sep 2;158(5):833-9. PubMed
  2. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell. 2002 Sep 20;110(6):673-87. PubMed

  New Migration Models for protrusion and adhesive signaling.

  1) Application of Bayesian networks to model focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK) in response to fibronectin binding to an integrin. 2) Mathematical model describing actin dynamics in protrusion.

1. Sachs K , Gifford D , Jaakkola T , Sorger P , Lauffenburger DA. Bayesian network approach to cell signaling pathway modeling. Sci STKE. 2002 Sep 3;2002(148):PE38. PubMed
2. Mogilner A , Edelstein-Keshet L. Regulation of actin dynamics in rapidly moving cells: a quantitative analysis. Biophys J. 2002 Sep;83(3):1237-58. PubMed

July 2002

• A featured article highlights computational Cell Biology

  A recent Nature Jobs article highlights computational cell biology as an emerging discipline, combining biology with maths and computer science with the ultimate goal of generating computer models of the living cells. Link to the article.

February 2002

• Publication Highlights

  In the January edition of Nature Medicine Consortium scientists report on studies using transgenic mice lacking beta3 integrin or beta3 and beta5 integrins, demonstrating a role for these integrins in blood vessel development.

  Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X, Sheppard D, Hynes RO, Hodivala-Dilke KM. Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nature Medicine 2002 Jan;8(1):27-34.PubMed